Ankitha Menon, Shabana Neermunda, Rasheed P Abdul
Department of Chemistry, Indian Institute of Technology Palakkad, Palakkad, Kerala 678 557 India.
Department of Biological Sciences and Engineering, Indian Institute of Technology Palakkad, Palakkad, Kerala 678 557 India.
Graphene 2D Mater. 2023;8(1-2):27-37. doi: 10.1007/s41127-022-00055-x. Epub 2022 Dec 17.
The electrochemical detection of dipyridamole (DIPY) is highly essential since it is extensively used for the treatment of cardiovascular diseases and to impart inhibitory effects for cancer patients. In this work, we report the development of a novel composite of MXene and ReS (ReS-NbCT ) by hydrothermal method. It was found that NbCT was partially oxidized and ReS nanoparticles were distributed on the surface of NbCT during the hydrothermal synthesis. The ReS-NbCT was used to modify carbon cloth electrodes and used for the electrochemical detection of DIPY. The ratio of ReS was optimized in the composite by varying the atomic ratio from 4 to 9 and it was found that 6ReS-NbCT showed the best sensing characteristics owing to the optimum interaction between ReS and NbCT . The developed sensor was able to detect DIPY linearly in the range 100 pM-1 μM and achieved a limit of detection of (LOD) of 28 pM. The modified electrode exhibited excellent selectivity towards DIPY in the presence of other interferents in addition to its good storage stability and repeatability. Furthermore, the developed sensor was also used for the detection of DIPY in human serum samples. Thus, this work paves the way to develop MXene-based platform for fabrication of flexible device capable of monitoring the acute levels of DIPY.
The online version contains supplementary material available at 10.1007/s41127-022-00055-x.
双嘧达莫（DIPY）的电化学检测至关重要，因为它被广泛用于治疗心血管疾病并对癌症患者产生抑制作用。在这项工作中，我们报告了通过水热法开发的一种新型的MXene与ReS（ReS-NbCT ）复合材料。发现在水热合成过程中，NbCT 被部分氧化，并且ReS纳米颗粒分布在NbCT 的表面。将ReS-NbCT 用于修饰碳布电极，并用于DIPY的电化学检测。通过将原子比从4变化到9来优化复合材料中ReS的比例，发现6ReS-NbCT 由于ReS与NbCT 之间的最佳相互作用而表现出最佳的传感特性。所开发的传感器能够在100 pM-1 μM范围内线性检测DIPY，检测限（LOD）达到28 pM。除了具有良好的储存稳定性和重复性外，修饰电极在存在其他干扰物的情况下对DIPY表现出优异的选择性。此外，所开发的传感器还用于检测人血清样品中的DIPY。因此，这项工作为开发基于MXene的平台以制造能够监测DIPY急性水平的柔性设备铺平了道路。
在线版本包含可在10.1007/s41127-022-00055-x获取的补充材料。
