Xiao Fei, Hu Yuxin, Wang Yuan, Zhang Yuxin, Zhou Enhui, Yang Tingting, Hong Feng
School of Public Health, the Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang, 561113, China.
Cardiovasc Toxicol. 2025 Jun 6. doi: 10.1007/s12012-025-10004-8.
Metabolic Syndrome (MetS) is a major public health problem that has imposed enormous socio-economic burdens in most countries and regions. This study aims to investigate the association of urinary Zinc (Zn) with the risk of MetS and its components among the Bouyei ethnic group, and the role of liver enzymes as mediators in this relationship. Zn concentrations in the urine of 5033 participants were measured by inductively coupled plasma mass spectrometry. An automatic biochemical analyzer was used to detect blood biochemical indexes. Binary logistic regression showed that compared with Q1, the OR (95% CI) for MetS, hyperglycemia, and elevated triglyceride in Q4 were 2.22 (1.69-2.92), 2.35 (1.73-3.18), and 1.38 (1.15-1.66), respectively. The results of the mediation analysis showed that liver enzyme may act as a partial mediator of the association between urinary Zn and MetS, with the mediating effect of gamma glutamyl transferase (GGT) accounting for 11.60% of the total effect. In conclusion, we found that urinary Zn was positively associated with MetS and its components among the Bouyei ethnic group in Guizhou Province. GGT appeared to play a partial mediating role between urinary Zn and the risk of MetS.
代谢综合征（MetS）是一个重大的公共卫生问题，在大多数国家和地区都带来了巨大的社会经济负担。本研究旨在探讨布依族人群尿锌（Zn）与MetS及其组分风险之间的关联，以及肝酶在这种关系中作为中介的作用。采用电感耦合等离子体质谱法测定5033名参与者尿液中的锌浓度。使用自动生化分析仪检测血液生化指标。二元逻辑回归显示，与第一四分位数（Q1）相比，第四四分位数（Q4）中MetS、高血糖和甘油三酯升高的比值比（OR，95%置信区间）分别为2.22（1.69 - 2.92）、2.35（1.73 - 3.18）和1.38（1.15 - 1.66）。中介分析结果表明，肝酶可能作为尿锌与MetS之间关联的部分中介，γ-谷氨酰转移酶（GGT）的中介效应占总效应的11.60%。总之，我们发现贵州省布依族人群中尿锌与MetS及其组分呈正相关。GGT似乎在尿锌与MetS风险之间起部分中介作用。
