Jiang Peihua, Rawson Nancy E
Monell Chemical Senses Center Philadelphia Pennsylvania United States.
Am J Physiol Cell Physiol. 2025 Jul 1;329(1):C136-C144. doi: 10.1152/ajpcell.00047.2025. Epub 2025 Jun 6.
Over the past decade, tremendous progress has been made in using organoids-three-dimensional, miniature organ-like structures-to model tissues and organs in vitro, including both regenerative tissues (which contain tissue-residing stem/progenitor cells) and largely nonregenerative tissues, such as the brain. Organoids resemble the tissues from which they are derived in many aspects of structure, function, and organization. As a result, organoid models have been used in a variety of fields for cell studies. Many well-written reviews have provided in-depth descriptions of organoid models for various systems. In this article, we review the establishment and application of tissue stem/progenitor cell-derived organoid models relevant to chemosensory cell studies (taste and smell) and discuss the limitations and future directions of using these models to study chemosensation.
在过去十年中，利用类器官（三维的、微型的器官样结构）在体外模拟组织和器官取得了巨大进展，这些组织和器官包括再生组织（含有组织驻留干细胞/祖细胞）以及很大程度上不可再生的组织，如大脑。类器官在结构、功能和组织的许多方面都类似于它们所源自的组织。因此，类器官模型已在细胞研究的各个领域得到应用。许多撰写精良的综述对各种系统的类器官模型进行了深入描述。在本文中，我们回顾了与化学感应细胞研究（味觉和嗅觉）相关的组织干细胞/祖细胞来源的类器官模型的建立和应用，并讨论了使用这些模型研究化学感应的局限性和未来方向。
