Hadley Liza, Rich Caylyn, Tasker Alex, Restif Olivier, Funk Sebastian
Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.
Centre for the Mathematical Modelling of Infectious Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom.
PLOS Glob Public Health. 2025 Jun 6;5(6):e0004675. doi: 10.1371/journal.pgph.0004675. eCollection 2025.
This study examines the use and translation of epidemiological modelling by policy and decision makers in response to the COVID-19 outbreak. Prior to COVID-19, there was little readiness for global health systems, and many science-policy networks were assembled ad-hoc. Moreover, in the field of epidemiological modelling, one with significant sudden influence, there is still no international guidance or standard of practice on how modelled evidence should guide policy during major health crises. Here we use a multi-country case study on the use of epidemiological modelling in emergency COVID-19 response, to examine the effective integration of crisis science and policy in different countries. We investigated COVID-19 modelling-policy systems and practices in 13 countries, spanning all six UN geographic regions. Data collection took the form of expert interviews with a range of national policy/ decision makers, scientific advisors, and modellers. We examined the current use of epidemiological modelling, introduced a classification framework for outbreak modelling and policy on which best practice can be structured, and provided preliminary recommendations for future practice. Full analysis and interpretation of the breadth of interview responses is presented, providing evidence for the current and future use of modelling in disease outbreaks. We found that interviewees in countries with a similar size and type of modelling infrastructure, and similar level of government interaction with modelling reported similar experiences and recommendations on using modelling in outbreak response. From this, we introduced a helpful grouping of country experience upon which a tailored future best practice could be structured. We concluded the article by outlining context-specific activities that modellers and policy actors could consider implementing in their own countries. This article serves as a first evidence base for the current use of modelling in a recent major health crisis and provides a robust framework for developing epidemiological modelling-to-policy best practice.
本研究考察了政策制定者和决策者为应对新冠疫情而对流行病学模型的使用及翻译情况。在新冠疫情之前,全球卫生系统几乎没有做好准备,许多科学政策网络都是临时组建的。此外,在具有重大突发影响力的流行病学建模领域,对于在重大健康危机期间模型证据应如何指导政策,仍然没有国际指导或实践标准。在此,我们通过一项关于在新冠疫情应急中使用流行病学建模的多国案例研究,来考察不同国家危机科学与政策的有效整合情况。我们调查了联合国所有六个地理区域的13个国家的新冠疫情建模政策体系及实践。数据收集采用了对一系列国家政策/决策者、科学顾问和建模人员进行专家访谈的形式。我们考察了流行病学建模的当前使用情况,引入了一个可用于构建最佳实践的疫情建模与政策分类框架,并为未来实践提供了初步建议。本文呈现了对访谈回复广度的全面分析和解读,为疾病爆发建模的当前及未来使用提供了证据。我们发现,建模基础设施规模和类型相似、政府与建模互动水平相似的国家的受访者,在疫情应对中使用建模方面报告了相似的经历和建议。据此,我们引入了一种有益的国家经验分组,可据此构建量身定制的未来最佳实践。我们在文章结尾概述了建模人员和政策行动者在其本国可考虑实施的具体情境活动。本文作为近期重大健康危机中建模当前使用情况的首个证据基础,为制定流行病学建模到政策的最佳实践提供了一个有力框架。