Ishida Natsuki, Takebe Tomohiro, Takahashi Kenichi, Asai Yusuke, Matsuura Tomoharu, Yamade Mihoko, Iwaizumi Moriya, Hamaya Yasushi, Yamada Takanori, Osawa Satoshi, Sugimoto Ken
First Department of Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama, Chuo-ku, Hamamatsu, Shizuoka, 431-3192, Japan.
Department of Laboratory Medicine, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.
Sci Rep. 2025 Jun 6;15(1):19916. doi: 10.1038/s41598-025-04908-2.
The diagnostic performance and clinical utility of fecal calprotectin (FC), fecal immunochemical occult blood test (FIT), leucine-rich alpha-2 glycoprotein (LRG), C-reactive protein (CRP), and prostaglandin E-major urinary metabolite (PGE-MUM) as established biomarkers for ulcerative colitis (UC) were evaluated. Significant correlations were observed between the clinical activity index, Mayo endoscopic subscore (MES), and each biomarker. Among MES groups, fecal biomarkers demonstrated significant differences, except between MES 2 and MES 3. CRP and LRG showed significant differences, except between MES 1 and MES 2. PGE-MUM exhibited significant differences across all MES groups. Areas under the curve (AUCs) for receiver operating characteristic (ROC) analysis in predicting MES 0 or 1 were as follows: FC, 0.891; FIT, 0.853; LRG, 0.723; CRP, 0.747; PGE-MUM, 0.795. For predicting MES 0 alone, AUCs were as follows: FC, 0.885; FIT, 0.845; LRG, 0.708; CRP, 0.691; PGE-MUM, 0.732. In distinguishing between each MES group, fecal biomarkers exhibited the highest AUC and accuracy in differentiating MES 0 from MES 1, whereas LRG, CRP, and PGE-MUM were most effective in differentiating MES 2 from MES 3. In summary, in UC, fecal biomarkers effectively detect mucosal healing, whereas LRG, CRP, and PGE-MUM are valuable for assessing mucosal healing and active inflammation.
评估了粪便钙卫蛋白（FC）、粪便免疫化学潜血试验（FIT）、富含亮氨酸的α-2糖蛋白（LRG）、C反应蛋白（CRP）和前列腺素E主要尿代谢物（PGE-MUM）作为溃疡性结肠炎（UC）既定生物标志物的诊断性能和临床效用。观察到临床活动指数、梅奥内镜亚评分（MES）与每种生物标志物之间存在显著相关性。在MES组中，除MES 2和MES 3之间外，粪便生物标志物显示出显著差异。CRP和LRG显示出显著差异，除MES 1和MES 2之间外。PGE-MUM在所有MES组中均表现出显著差异。预测MES 0或1时，受试者工作特征（ROC）分析的曲线下面积（AUC）如下：FC为0.891；FIT为0.853；LRG为0.723；CRP为0.747；PGE-MUM为0.795。仅预测MES 0时，AUC如下：FC为0.885；FIT为0.845；LRG为0.708；CRP为0.691；PGE-MUM为0.732。在区分每个MES组时，粪便生物标志物在区分MES 0和MES 1方面表现出最高的AUC和准确性，而LRG、CRP和PGE-MUM在区分MES 2和MES 3方面最有效。总之，在UC中，粪便生物标志物可有效检测黏膜愈合，而LRG、CRP和PGE-MUM在评估黏膜愈合和活动性炎症方面具有重要价值。
