First Department of Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, 431-3192, Japan.
Department of Endoscopic and Photodynamic Medicine, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.
BMC Gastroenterol. 2020 Apr 19;20(1):114. doi: 10.1186/s12876-020-01256-5.
Prostaglandin E-major urinary metabolite (PGE-MUM) may be a novel biomarker for evaluating disease activity in ulcerative colitis (UC). We compared its usefulness to that of the fecal immunochemical occult blood test (FIT).
PGE-MUM and FIT measurements were performed of 92 urinary and fecal samples obtained from 60 patients with UC. Endoscopic activity was determined by Mayo endoscopic subscore (eMayo) and Ulcerative Colitis Endoscopic Index of Severity (UCEIS) score.
PGE-MUM levels and FIT results showed a significant correlation with respect to eMayo (P < 0.001 and P < 0.001, respectively), and there was a significant difference in PGE-MUM values between the groups below eMayo1 and above eMayo2 (P = 0.012). Both biomarkers were significantly correlated with the UCEIS score (P < 0.001 and P < 0.001, respectively), and the PGE-MUM values were significantly different between groups below UCEIS1 and above UCEIS2 (P = 0.012). PGE-MUM and FIT were significantly correlated with eMayo in the group with a disease duration < 5 years (P = 0.041 and P < 0.001, respectively). Although PGE-MUM and eMayo differed significantly between groups over 5 years (P = 0.012), FIT was not correlated with eMayo (P = 0.101).
PGE-MUM is useful as a biomarker as FIT for evaluating the endoscopic activity, particularly in long-term affected patients with UC.
前列腺素 E-主要尿代谢产物（PGE-MUM）可能是评估溃疡性结肠炎（UC）疾病活动的新型生物标志物。我们比较了其与粪便免疫化学隐血试验（FIT）的实用性。
对 60 例 UC 患者的 92 份尿液和粪便样本进行了 PGE-MUM 和 FIT 测量。通过 Mayo 内镜亚评分（eMayo）和溃疡性结肠炎内镜严重程度指数（UCEIS）评分确定内镜活动度。
PGE-MUM 水平和 FIT 结果与 eMayo 显著相关（分别为 P < 0.001 和 P < 0.001），eMayo 评分低于 1 分和高于 2 分的两组之间的 PGE-MUM 值存在显著差异（P = 0.012）。两种生物标志物与 UCEIS 评分均显著相关（分别为 P < 0.001 和 P < 0.001），UCEIS 评分低于 1 分和高于 2 分的两组之间的 PGE-MUM 值存在显著差异（P = 0.012）。在疾病病程<5 年的患者中，PGE-MUM 和 eMayo 与 FIT 显著相关（分别为 P = 0.041 和 P < 0.001）。尽管 PGE-MUM 和 eMayo 在病程超过 5 年的患者中差异显著（P = 0.012），但 FIT 与 eMayo 无相关性（P = 0.101）。
PGE-MUM 作为 FIT 的生物标志物可用于评估内镜活动度，特别是在病程较长的 UC 患者中。
