Department of Gastroenterology, Nutrition, and Endocrinology, Osaka Women's and Children's Hospital, 840 Murodocho, Izumi, Osaka, 594-1101, Japan.
Division of Infectious Diseases and Immunology, Aichi Children's Health and Medical Center, Aichi, Japan.
Sci Rep. 2023 Jun 19;13(1):9898. doi: 10.1038/s41598-023-37145-6.
Prostaglandin E-major urinary metabolite (PGE-MUM) is a urinary biomarker reflecting ulcerative colitis (UC) activity. This prospective observational study aimed to evaluate the usefulness of PGE-MUM via rapid chemiluminescent enzyme immunoassay in detecting endoscopic remission (ER) and histologic remission (HR) in pediatric UC (6-16 years) in comparison with fecal calprotectin (FCP). ER and HR were defined as Mayo endoscopic score (MES) of 0 and Matts' histological grades (Matts) of 1 or 2, respectively. A total of 104 UC and 39 functional gastrointestinal disorder (FGID) were analyzed. PGE-MUM levels were significantly higher in the UC group than in the FGID group (P < 0.001). FCP levels were significantly elevated in the group without ER and HR than in the group with ER and HR (P < 0.001 and P = 0.001), whereas PGE-MUM levels were significantly higher in the group without ER compared to the group with ER (P < 0.001). No significant differences were noted in the AUCs for PGE-MUM and FCP in detecting ER and HR. Although PGE-MUM was inferior to FCP for the detection of HR, it might have the potential for application as a biomarker of endoscopic activity in pediatric UC owing to its noninvasive and rapid method.
前列腺素 E 主要尿代谢产物（PGE-MUM）是一种反映溃疡性结肠炎（UC）活动的尿生物标志物。本前瞻性观察研究旨在通过快速化学发光酶免疫分析评估 PGE-MUM 在检测儿科 UC（6-16 岁）内镜缓解（ER）和组织学缓解（HR）中的作用，与粪便钙卫蛋白（FCP）相比。ER 和 HR 分别定义为 Mayo 内镜评分（MES）为 0 和 Matts 组织学分级（Matts）为 1 或 2。共分析了 104 例 UC 和 39 例功能性胃肠病（FGID）。UC 组的 PGE-MUM 水平明显高于 FGID 组（P<0.001）。无 ER 和 HR 组的 FCP 水平明显高于有 ER 和 HR 组（P<0.001 和 P=0.001），而无 ER 组的 PGE-MUM 水平明显高于有 ER 组（P<0.001）。PGE-MUM 和 FCP 检测 ER 和 HR 的 AUC 之间无显著差异。虽然 PGE-MUM 在检测 HR 方面劣于 FCP，但由于其非侵入性和快速方法，它可能具有作为儿科 UC 内镜活动生物标志物的应用潜力。
