Nahas G, Trouve R
Proc Soc Exp Biol Med. 1985 Nov;180(2):312-6. doi: 10.3181/00379727-180-42181.
A Langendorff perfused rat heart preparation was designed to process dose-response effects of cardioactive drugs on rate, coronary flow, and supraaortic differential pressure (delta P; an index of cardiac performance). In this preparation, delta 9- -tetrahydrocannabinol (THC) 2 X 10(-6) M to 10(-5) M induces in the isolated perfused rat heart a biphasic increase in rate (maximal at 8 X 10(-6) M). Tachycardia is associated with decreases in (delta P) and no change or decreased coronary flow. Cardiac toxicity is observed with 3 X 10(-5) M. Cannabidiol (CBD) at concentrations of 9 X 10(-6) M to 10(-4) M has limited effect on rate while increasing delta P and coronary flow. Cannabinol (CBN) 8 X 10(-6) M to 3 X 10(-4) M depresses rate and delta P while coronary flow remains constant. Simultaneous equimolar administration of THC with CBD antagonizes or mitigates the cardiac effects of THC on rate, delta P, and coronary flow.
设计了一种Langendorff灌流大鼠心脏标本，用于研究心血管活性药物对心率、冠脉流量和主动脉上压差（ΔP；心脏功能指标）的剂量反应效应。在该标本中，Δ⁹-四氢大麻酚（THC）2×10⁻⁶ M至10⁻⁵ M可使离体灌流大鼠心脏的心率呈双相增加（在8×10⁻⁶ M时达到最大值）。心动过速与ΔP降低相关，冠脉流量无变化或减少。在3×10⁻⁵ M时可观察到心脏毒性。浓度为9×10⁻⁶ M至10⁻⁴ M的大麻二酚（CBD）对心率影响有限，同时增加ΔP和冠脉流量。大麻酚（CBN）8×10⁻⁶ M至3×10⁻⁴ M可降低心率和ΔP，而冠脉流量保持不变。THC与CBD等摩尔同时给药可拮抗或减轻THC对心率、ΔP和冠脉流量的心脏效应。
