Seale T W, Carney J M, Johnson P, Rennert O M
Pharmacol Biochem Behav. 1985 Sep;23(3):373-7. doi: 10.1016/0091-3057(85)90008-5.
Two inbred strains of mice, DBA/2 and C57BL/6, differ in their responses to d-amphetamine-induced alteration of core temperature. At low doses of amphetamine (e.g., 2 mg/kg IP), both strains become markedly hypothermic within 10-20 minutes. High doses (e.g., 20 mg/kg IP) induce significant hyperthermia (+1.8 degrees C) in DBA/2 mice but have only a slight hyperthermic effect (+0.2-0.3 degrees C) effect on C57BL/6 mice. The phenotype of the F1 hybrid strain derived by crossing C57BL/6 by DBA/2 is indistinguishable from its C57BL/6 parent at a dose of 20 mg/kg IP, i.e., reduced responsiveness to amphetamine-induced hyperthermia is dominant. Analysis of the thermoregulatory responses of recombinant inbred derivatives (lines BXD-9, 11, 15, 19, 20, 21, 23, 27, 28, 30) suggest that the relative responses to amphetamine-induced hyperthermia is inherited in a simple Mendelian fashion. These results differ from other pairs of inbred mouse strains which have been compared. These findings identify yet another neuropharmacological difference between mouse strains C57BL/6 and DBA/2 and are reviewed in terms of neuroregulatory mechanisms effecting thermoregulation.
两种近交系小鼠，DBA/2和C57BL/6，对右旋苯丙胺引起的核心体温变化反应不同。在低剂量苯丙胺（如腹腔注射2毫克/千克）时，两种品系在10 - 20分钟内都会显著体温过低。高剂量（如腹腔注射20毫克/千克）会使DBA/2小鼠产生显著的体温过高（升高1.8摄氏度），但对C57BL/6小鼠只有轻微的体温过高效应（升高0.2 - 0.3摄氏度）。通过将C57BL/6与DBA/2杂交得到的F1杂交品系，在腹腔注射20毫克/千克剂量时，其表型与C57BL/6亲本无法区分，即对苯丙胺诱导的体温过高反应性降低是显性的。对重组近交衍生物（BXD - 9、11、15、19、20、21、23、27、28、30系）的体温调节反应分析表明，对苯丙胺诱导的体温过高的相对反应是以简单的孟德尔方式遗传的。这些结果与其他已比较的近交系小鼠对不同。这些发现确定了C57BL/6和DBA/2小鼠品系之间的另一种神经药理学差异，并从影响体温调节的神经调节机制方面进行了综述。
