He Jiaoyan, Yan Xiuwei, Hu Shaoshan
Cancer Center, Department of Neurosurgery, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, China.
Stem Cell Res Ther. 2025 Jun 7;16(1):293. doi: 10.1186/s13287-025-04352-z.
Glioma, a common malignancy of the central nervous system, attracts significant clinical attention due to its poor prognosis. Glioma stem cells (GSCs), characterized by stem-like properties and substantial heterogeneity, play a crucial role in tumor initiation, progression, and potential recurrence. Moreover, through complex interaction mechanisms, they contribute to the challenges associated with treatment. This review seeks to explore the distinctive characteristics and underlying mechanisms of GSCs, aiming to provide novel theoretical insights and practical strategies for precision therapy in glioma.
胶质瘤是中枢神经系统常见的恶性肿瘤，因其预后较差而备受临床关注。胶质瘤干细胞（GSCs）具有干细胞样特性和显著的异质性，在肿瘤的起始、进展及潜在复发中起关键作用。此外，通过复杂的相互作用机制，它们给治疗带来了挑战。本综述旨在探讨胶质瘤干细胞的独特特征和潜在机制，为胶质瘤的精准治疗提供新的理论见解和实践策略。
