Garza Jay, Chong Benjamin F
Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Lupus. 2025 Aug;34(9):972-977. doi: 10.1177/09612033251349451. Epub 2025 Jun 8.
BackgroundLupus erythematosus panniculitis (LEP) is a rare variant of cutaneous lupus erythematosus that typically presents as indurated nodules or plaques. Calcinosis cutis (CC) is a potential complication of this disease with limited treatment modalities and significant quality of life complications. The rate and risk factors of CC in LEP are not well understood. Thus, we conducted a retrospective cohort study on patients diagnosed with LEP.ObjectiveTo quantify the rate of CC and to identify the risk factors associated with its development in LEP.MethodsThis retrospective cohort study analyzed data from 27 LEP patients recruited in outpatient dermatology clinics at University of Texas Southwestern Medical Center and Parkland Health from January 2009 to December 2024. The primary outcome measure was CC development based on clinical diagnosis from a dermatologist, biopsy, or radiographic imaging. Data collected included demographics, smoking history, disease duration, medications, and lesion location. Predictor variables associated with CC development were analyzed either by Mann-Whitney U or Fisher's exact tests.Results10/27 (37%) LEP patients had CC during the evaluation period. LEP patients with CC had a higher rate of truncal involvement (9/10 (90%) versus 7/17 (41.2%); = .02) and a lower rate of head & neck involvement (3/10 (30%) versus 13/17 (76.5%); = .04) of their LEP lesions compared to those without CC.LimitationsThis study is limited by its single-center design, retrospective nature, and small sample size.ConclusionsThis cohort of LEP patients had over a third developing CC. LEP lesion location significantly differed in those who developed CC compared with those who did not. CC is a common complication of LEP that requires close monitoring by clinicians. Prospective multicenter studies are needed to confirm these findings and better understand the predictive factors for the development of CC in LEP patients.
背景
红斑狼疮性脂膜炎（LEP）是皮肤红斑狼疮的一种罕见变体，通常表现为硬结性结节或斑块。皮肤钙化（CC）是该疾病的一种潜在并发症，治疗方式有限，且会引发严重的生活质量问题。LEP中CC的发生率及危险因素尚不清楚。因此，我们对诊断为LEP的患者进行了一项回顾性队列研究。
目的
量化LEP中CC的发生率，并确定与其发生相关的危险因素。
方法
这项回顾性队列研究分析了2009年1月至2024年12月在德克萨斯大学西南医学中心和帕克兰健康中心门诊皮肤科招募的27例LEP患者的数据。主要结局指标是基于皮肤科医生的临床诊断、活检或影像学检查的CC发生情况。收集的数据包括人口统计学资料、吸烟史、病程、用药情况和皮损部位。通过曼-惠特尼U检验或费舍尔精确检验分析与CC发生相关的预测变量。
结果
在评估期间，27例LEP患者中有10例（37%）发生了CC。与未发生CC的LEP患者相比，发生CC的LEP患者其皮损累及躯干的比例更高（9/10（90%）对7/17（41.2%）；P = 0.02），累及头颈部的比例更低（3/10（30%）对13/17（76.5%）；P = 0.04）。
局限性
本研究受单中心设计、回顾性性质和样本量小的限制。
结论
这组LEP患者中有超过三分之一发生了CC。发生CC的患者与未发生CC的患者相比，LEP皮损部位有显著差异。CC是LEP的常见并发症，临床医生需要密切监测。需要进行前瞻性多中心研究来证实这些发现，并更好地了解LEP患者发生CC的预测因素。
