Vázquez-Morales Leonardo, Aguirre Gisela, Molina-Jiménez Tania, Zepeda Rossana C, López-Franco Óscar, Flores-Muñoz Mónica, Juárez-Portilla Claudia
Facultad de Biología, Universidad Veracruzana, Xalapa, Veracruz, Mexico.
Laboratorio de Neurobiología de la Conducta y Procesos Neuroquímicos, Centro de Investigaciones Biomédicas, Universidad Veracruzana, Xalapa, Veracruz, Mexico.
Addict Biol. 2025 Jun;30(6):e70046. doi: 10.1111/adb.70046.
Substance use disorder constitutes a global health challenge. Preclinical investigations into addiction heavily rely on animal models to explore the underlying biological mechanisms of addictive disorders, with a particular emphasis on understanding the etiological factors influencing drug intake. Exploring sex differences across various phases of addiction has revealed a heightened vulnerability in females. This study systematically reviews the impact of ovarian hormones on the consumption of psychoactive substances in rodents, adhering to the PRISMA 2009 protocol. Our findings underscore the significant role of ovarian hormones, particularly oestrogen, in augmenting drug consumption among female rodents. Notably, with heroin, it was observed that progesterone, rather than oestrogen, facilitated increased consumption in female rodents. The susceptibility to addiction influenced by oestrogen is accentuated across distinct phases, and the molecular mechanisms form a complex interplay that significantly influences addictive behaviours. By bringing together these findings, we aim to establish a strong foundation for future studies. This work may guide clinical investigations in developing more effective prevention or treatment strategies that address the unique vulnerabilities of females to substance use disorders.
物质使用障碍是一项全球性的健康挑战。对成瘾的临床前研究严重依赖动物模型来探索成瘾性疾病的潜在生物学机制，尤其侧重于理解影响药物摄入的病因因素。对成瘾各个阶段的性别差异进行探索后发现，女性的易感性更高。本研究遵循PRISMA 2009方案，系统综述了卵巢激素对啮齿动物精神活性物质消费的影响。我们的研究结果强调了卵巢激素，特别是雌激素，在增加雌性啮齿动物药物消费方面的重要作用。值得注意的是，对于海洛因，观察到在雌性啮齿动物中，促进消费增加的是孕酮而非雌激素。雌激素影响的成瘾易感性在不同阶段都更为明显，其分子机制形成了复杂的相互作用，对成瘾行为有显著影响。通过整合这些研究结果，我们旨在为未来的研究奠定坚实基础。这项工作可能会指导临床研究，以制定更有效的预防或治疗策略，应对女性在物质使用障碍方面的独特易感性。
