Savage C O, Winearls C G, Evans D J, Rees A J, Lockwood C M
Q J Med. 1985 Aug;56(220):467-83.
We have described 34 patients with microscopic polyarteritis, all of whom had clinical evidence of a systemic small vessel vasculitis predominantly affecting the skin and musculoskeletal systems accompanied by a focal necrotising glomerulonephritis with renal impairment. Thirty three patients received immunosuppressive treatment, comprising prednisolone, azathioprine, cyclophosphamide and plasma exchange in various combinations. The five-year actuarial patient and kidney survival rates were 65 and 55 per cent respectively, suggesting that aggressive immunosuppressive therapy in these patients is beneficial.
我们描述了34例显微镜下多血管炎患者，所有患者均有系统性小血管炎的临床证据，主要累及皮肤和肌肉骨骼系统，并伴有局灶性坏死性肾小球肾炎及肾功能损害。33例患者接受了免疫抑制治疗，治疗方案包括不同组合的泼尼松龙、硫唑嘌呤、环磷酰胺及血浆置换。患者的5年精算生存率和肾脏生存率分别为65%和55%，提示对这些患者积极进行免疫抑制治疗是有益的。
