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颈部解剖结构复杂的破裂腹主动脉瘤血管腔内修复的形态学及预后

Morphology and outcomes of endovascular repair of ruptured abdominal aortic aneurysms with hostile neck anatomy.

作者信息

Pitcher Grayson S, Ford Benjamin C, Mix Doran, Newhall Karina S, Sen Indrani, Stoner Michael C, Mendes Bernardo C

机构信息

Division of Vascular Surgery, University of Rochester Medical Center, Rochester, NY.

Division of Vascular Surgery, University of Rochester Medical Center, Rochester, NY.

出版信息

J Vasc Surg. 2025 Oct;82(4):1243-1255. doi: 10.1016/j.jvs.2025.05.209. Epub 2025 Jun 6.

Abstract

OBJECTIVE

Ruptured abdominal aortic aneurysms (rAAAs) have a high rate of hostile neck anatomy (HNA). The objective of this study was to evaluate the risk factors associated with intraoperative type Ia endoleak (T1EL) in endovascular repair (EVAR) for rAAAs with HNA, and to determine the association of intra-operative T1EL with long-term survival. The second objective was to delineate the visceral anatomy of rAAAs with HNA to determine the anatomic feasibility of the Cook p-Branch device.

METHODS

A multi-center retrospective review was performed to identify patients with rAAAs and HNA between 2004 and 2021. HNA was defined as infrarenal aortic neck diameter >28 mm, infrarenal neck length <15 mm, or angulation >60 degrees. Clinical characteristics and morphology were reviewed for predictors of intraoperative T1EL. The Kaplan-Meier method was used to estimate survival. The anatomic feasibility of the Cook p-Branch was reviewed.

RESULTS

Eighty-five patients underwent standard EVAR for rAAAs with HNA. Mean age was 75 ± 10 years, and 74% were male. Twenty-four patients (28%) required adjunctive procedures for an intraoperative T1EL. Large aneurysm size (odds ratio [OR], 1.03; 95% confidence interval [CI], 1.00-1.05; P = .02), increased distance from the renal arteries to the aortic bifurcation (OR, 1.02; 95% CI, 1.00-1.04; P = .04) and lower thrombus burden (OR, 0.57; 95% CI, 0.34-0.96; P = .03) were associated with intraoperative T1EL and the need for adjunctive procedures on univariate analysis. Overall survival for patients who underwent standard EVAR at 30 days, 1 year, and 5 years was 84%, 74%, and 64%, respectively. There was no difference in 30-day (84% vs 83%; P = .99), 1-year (75% vs 71%; Log-rank P = .73), or 5-year survival (67% vs 54%; Log-rank P = .34) in patients without an intraoperative T1EL vs patients with a T1EL who required an adjunctive procedure. There was also no difference in 1-year (98% vs 96%; Log-rank P = .48) or 5-year (85% vs 92%; Log-rank P = .51) aortic-related reintervention. No specific morphologic features within this population were predictive of aortic-related reintervention at 5 years. The visceral vessel applicability of the Cook p-Branch was 65%, and the overall applicability was only 56%.

CONCLUSIONS

Despite a high rate of adjunctive intra-operative procedures for T1EL in patients who underwent EVAR for rAAAs with HNA, this was not associated with a significant difference in survival or aortic-related reintervention. The overall applicability of the Cook p-Branch device in patients with rAAAs and HNA is low, and standard EVAR is effective.

摘要

目的

破裂性腹主动脉瘤(rAAA)患者中,不良颈部解剖结构(HNA)的发生率较高。本研究的目的是评估HNA的rAAA患者在血管内修复术(EVAR)中发生术中Ia型内漏(T1EL)的相关危险因素,并确定术中T1EL与长期生存的关系。第二个目的是描绘HNA的rAAA的内脏解剖结构,以确定Cook p-Branch装置的解剖可行性。

方法

进行一项多中心回顾性研究,以确定2004年至2021年间患有rAAA和HNA的患者。HNA定义为肾下主动脉颈部直径>28 mm、肾下颈部长度<15 mm或成角>60度。回顾临床特征和形态学,以寻找术中T1EL的预测因素。采用Kaplan-Meier法估计生存率。评估Cook p-Branch的解剖可行性。

结果

85例HNA的rAAA患者接受了标准EVAR。平均年龄为75±10岁,74%为男性。24例患者(28%)因术中T1EL需要辅助手术。单因素分析显示,动脉瘤尺寸较大(比值比[OR],1.03;95%置信区间[CI],1.00 - 1.05;P = .02)、肾动脉至主动脉分叉的距离增加(OR,1.02;95% CI,1.00 - 1.04;P = .04)和血栓负荷较低(OR,0.57;95% CI,0.34 - 0.96;P = .03)与术中T1EL及辅助手术的需求相关。接受标准EVAR的患者在30天、1年和5年时的总体生存率分别为84%、74%和64%。术中无T1EL的患者与术中发生T1EL且需要辅助手术的患者在30天(84%对83%;P = .99)、1年(75%对71%;对数秩检验P = .73)或5年生存率(67%对54%;对数秩检验P = .34)方面无差异。在1年(98%对96%;对数秩检验P = .48)或5年(85%对92%;对数秩检验P = .51)的主动脉相关再次干预方面也无差异。该人群中没有特定的形态学特征可预测5年时的主动脉相关再次干预。Cook p-Branch在内脏血管的适用性为65%,总体适用性仅为56%。

结论

尽管HNA的rAAA患者在接受EVAR时术中因T1EL进行辅助手术的比例较高,但这与生存率或主动脉相关再次干预的显著差异无关。Cook p-Branch装置在HNA的rAAA患者中的总体适用性较低,标准EVAR是有效的。

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