Liang Honghong, Gan Zhengkun, Wang Yaodeng, Guo Yi, Wu Xinyu, He Run, Tao Aien, Ma Ling, Jiang Guihua
State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Hospital of Traditional Chinese Medicine, Chongqing 400021, China.
Int J Biol Macromol. 2025 Jul;318(Pt 3):145036. doi: 10.1016/j.ijbiomac.2025.145036. Epub 2025 Jun 6.
The genus Citrus L., recognized for its medicinal and nutritional properties, exhibits significant activities such as antioxidant, anti-inflammatory, and immunomodulatory effects. These characteristics have led to a wide range of applications in this genus. As a vital raw material, is utilized in 1066 Chinese patent medicines, 2935 traditional Chinese medicine prescriptions, 186 domestic health foods, and 4 imported health foods, contributing to the fields of food and healthcare. Recently, polysaccharides have become the focus of research, with applications spanning medicine, food, and materials. Consequently, this study systematically reviews the genus Citrus L. polysaccharides (CGPs), addressing the research advancements in extraction, purification, structural characteristics, biological activities, and applications. It also examines how factors such as polysaccharide molecular weight, monosaccharide composition, and configuration, influence biological activities. The key conclusions indicate that CGPs with specific monosaccharide profiles (e.g., high GalA content) exhibit enhanced bioactivity, particularly in immunomodulation and antioxidant effects. This review aims to enhance the understanding of CGPs and facilitate their application and development. Future research should focus on integrating multidisciplinary technologies, optimizing extraction processes, conducting in-depth analyses of structure-function relationships, and exploring the potential applications in medicine and environmentally friendly materials, thereby promoting the high-value utilization and industrial development of CGPs.
柑橘属（Citrus L.）以其药用和营养特性而闻名，具有抗氧化、抗炎和免疫调节等显著活性。这些特性使得该属植物有广泛的应用。作为一种重要的原材料，它被用于1066种中成药、2935个中药方剂、186种国产保健食品和4种进口保健食品中，为食品和医疗保健领域做出了贡献。近年来，多糖已成为研究热点，其应用涵盖医药、食品和材料等领域。因此，本研究系统地综述了柑橘属多糖（CGPs），阐述了其在提取、纯化、结构特征、生物活性及应用方面的研究进展。还探讨了多糖分子量、单糖组成和构型等因素如何影响生物活性。关键结论表明，具有特定单糖谱（如高半乳糖醛酸含量）的CGPs表现出更强的生物活性，尤其是在免疫调节和抗氧化作用方面。本综述旨在增进对CGPs的理解，促进其应用与开发。未来的研究应聚焦于整合多学科技术、优化提取工艺、深入分析结构-功能关系以及探索在医药和环保材料方面的潜在应用，从而推动CGPs的高值利用和产业发展。
