Policar Clotilde
Laboratoire Chimie physique et chimie du vivant, CPCV, Département de Chimie de l'ENS-PSL, Ecole Normale Supérieure, ENS-PSL, PSL University, Sorbonne Université, CNRS, 24 rue Lhomond, 75005, Paris, France.
J Biol Inorg Chem. 2025 Jun 8. doi: 10.1007/s00775-025-02112-1.
Bioinorganic chemistry is a multidisciplinary field that bridges the apparent divide between inorganic chemistry and biology. The very name "bioinorganic" is an intriguing oxymoron, as "inorganic" chemistry traditionally refers to the study of the inanimate world, while the "bio" prefix refers to living systems. Bioinorganic chemistry focuses on metallic systems within biological environments, with the dual aims of better understanding these natural systems and leveraging the solutions developed through evolution to design new industrial or therapeutic applications. As a close cousin of the field of metallomics, bioinorganic chemistry shares the fundamental principles that underpin metallomics' systemic analyses of metal-containing biomolecules. In this article, we trace the historical development of bioinorganic chemistry, highlighting its recent advancements and outlining future research challenges in this dynamic interdisciplinary area.
生物无机化学是一个多学科领域，它弥合了无机化学与生物学之间明显的鸿沟。“生物无机”这个名字本身就是一个有趣的矛盾修饰法，因为传统上“无机”化学指的是对无生命世界的研究，而“生物”前缀则指的是生命系统。生物无机化学专注于生物环境中的金属体系，旨在更好地理解这些自然体系，并利用通过进化发展而来的解决方案来设计新的工业或治疗应用。作为金属组学领域的近亲，生物无机化学与金属组学对含金属生物分子进行系统分析所依据的基本原理相同。在本文中，我们追溯了生物无机化学的历史发展，突出了其近期的进展，并概述了这个充满活力的跨学科领域未来的研究挑战。
