Ho Man Kit, Safavi Golnesa, Jeon Won Jin, Mendoza Evelyn
Department of Internal Medicine, Loma Linda University Medical Center - Murrieta, Murrieta, CA, United States.
Division of Medical Oncology and Hematology, Department of Internal Medicine, Loma Linda University, Loma Linda, CA, United States.
Front Oncol. 2025 May 23;15:1545896. doi: 10.3389/fonc.2025.1545896. eCollection 2025.
Ewing sarcoma (ES), particularly Extra-skeletal Ewing sarcoma (EES), is a rare, aggressive tumor predominantly affecting adolescents and young adults, yet it can occur in older patients, leading to misdiagnosis and delay in treatment. The standard approach includes surgical resection, chemotherapy, and radiation therapy for unresectable disease. This case report presents a 63-year-old female patient with a history of triple-negative breast cancer, who was discovered to have a soft tissue tumor in the left medial thigh. Initially misdiagnosed as rhabdomyosarcoma, the diagnosis of EES was ultimately confirmed via RNA sequencing revealing the EWSR1-FLI1 fusion gene. She underwent neoadjuvant chemotherapy followed by radical resection of the tumor.
尤因肉瘤（ES），特别是骨外尤因肉瘤（EES），是一种罕见的侵袭性肿瘤，主要影响青少年和年轻成年人，但也可发生于老年患者，导致误诊和治疗延误。标准治疗方法包括手术切除、化疗以及对不可切除疾病进行放射治疗。本病例报告介绍了一名63岁的女性患者，她有三阴性乳腺癌病史，在左大腿内侧发现一个软组织肿瘤。最初被误诊为横纹肌肉瘤，最终通过RNA测序发现EWSR1-FLI1融合基因确诊为EES。她接受了新辅助化疗，随后进行了肿瘤根治性切除。
