Daher Mohammad, Zalaquett Ziad, Chalhoub Ralph, Abi Farraj Sami, Abdo Majd, Sebaaly Amer, Kourie Hampig-Raphaël, Ghanem Ismat
Orthopedic Department, Faculty of Medicine, Saint Joseph University of Beirut, Lebanon.
Hematology-Oncology Department, Faculty of Medicine, Saint Joseph University of Beirut, Lebanon.
J Bone Oncol. 2023 Apr 26;40:100482. doi: 10.1016/j.jbo.2023.100482. eCollection 2023 Jun.
With an annual incidence of less than 1%, Ewing sarcoma mainly occurs in children and young adults. It is not a frequent tumor but is the second most common bone malignancy in children. It has a 5-year survival rate of 65-75%; however, it has a poor prognosis when it relapses in patients. A genomic profile of this tumor can potentially help identify poor prognosis patients earlier and guide their treatment. A systematic review of the articles concerning genetic biomarkers in Ewing sarcoma was conducted using the Google Scholar, Cochrane, and PubMed database. There were 71 articles discovered. Numerous diagnostic, prognostic, and predictive biomarkers were found. However, more research is necessary to confirm the role of some of the mentioned biomarkers. .
尤因肉瘤的年发病率低于1%，主要发生在儿童和年轻人中。它不是一种常见肿瘤，但却是儿童中第二常见的骨恶性肿瘤。其5年生存率为65% - 75%；然而，患者复发时预后较差。该肿瘤的基因组图谱可能有助于更早地识别预后不良的患者并指导其治疗。我们使用谷歌学术、考克兰和PubMed数据库对有关尤因肉瘤基因生物标志物的文章进行了系统综述。共发现71篇文章。发现了许多诊断、预后和预测性生物标志物。然而，需要更多研究来证实其中一些提及的生物标志物的作用。
