Ghandour Maher, Semaan Karl, Saad Eddy, Horsch Axel, Abdallah Ralph, Semaan Doumit
Orthopedics Department, Heidelberg University Hospital, Germany.
Orthopedics Department, Lebanese University, Lebanon.
J Orthop. 2023 Sep 9;44:86-92. doi: 10.1016/j.jor.2023.09.002. eCollection 2023 Oct.
Evidence suggests different presentation patterns and prognosis of extraosseous Ewing Sarcoma (EES) based on age. Thus, we carried out this study to test the difference between children and adult EES cases regarding clinicodemographic characteristics and prognosis.
A total of 4 databases were explored yielding 18 relevant studies for data synthesis. Outcomes included the comparison of demographic and clinical characteristics as well as prognosis between children and adults with EES. Log odds ratio (logOR) and its 95% confidence interval (CI) were pooled across studies. Statistical models/methods were selected based on heterogeneity.
Our analysis included a total of 1261 children and 1256 adults. When we compared these two age categories, we did not observe a significant difference in the risk of developing EES [logOR = -0.13; 95% CI: -0.65: 0.39; I2 = 88.42%]. No significant differences regarding gender, tumor location, and size (≤5 vs. >5 cm), EWSR1 positivity, or management modality. We did not observe significant difference regarding clinical outcomes, such as 5-year overall survival and event-free survival, recurrence, mortality, no evidence of disease, and secondary metastasis.
Our findings highlight the absence of an association between the age category of patients and the incidence of EES, as well as its clinical outcomes.
有证据表明，骨外尤文肉瘤（EES）的表现模式和预后因年龄而异。因此，我们开展了这项研究，以检验儿童和成人EES病例在临床人口统计学特征和预后方面的差异。
共检索了4个数据库，得到18项相关研究用于数据合成。结果包括对EES儿童和成人的人口统计学和临床特征以及预后进行比较。对各研究的对数比值比（logOR）及其95%置信区间（CI）进行合并。根据异质性选择统计模型/方法。
我们的分析共纳入了1261名儿童和1256名成人。当我们比较这两个年龄组时，未观察到发生EES风险的显著差异[logOR = -0.13；95% CI：-0.65：0.39；I2 = 88.42%]。在性别、肿瘤位置和大小（≤5 vs.>5 cm）、EWSR1阳性或治疗方式方面无显著差异。我们未观察到临床结局方面的显著差异，如5年总生存率和无事件生存率、复发、死亡率、无疾病证据和继发转移。
我们的研究结果表明，患者年龄类别与EES的发病率及其临床结局之间不存在关联。
