Wan Naijun, Zhang Qian, Zhang Jin, Zhang Tian, Shi Weijia
Department of Pediatrics, Beijing Jishuitan Hospital, Capital Medical University, Beijing, People's Republic of China.
Diabetes Metab Syndr Obes. 2025 Jun 2;18:1837-1847. doi: 10.2147/DMSO.S521357. eCollection 2025.
To investigate the relationship between serum uric acid (SUA) levels and bone mineral density (BMD) in children with obesity.
229 children with obesity were included in the study, and their blood SUA, fasting plasma glucose (FPG), glycosylated hemoglobin (HbAlc), calcium (Ca), phosphorus (P), 25-hydroxyvitamin D (25(OH)D) and other indicators were measured. Distal forearm BMD was assessed at the radius and ulna. Differences in these indicators were compared across different genders and age groups.
BMD showed significant differences between genders and age groups. The BMD Z-score in the 6-9 years group was higher than that in the 10-12 years group for both boys (-0.13 ± 0.92 vs -1.27 ± 0.62, p = 0.000) and girls (0.68 ± 0.96 vs -0.03 ± 0.73, p = 0.001). Serum SUA levels in the 6-9 years group were lower than those in the 10-12 years group for both boys (345.9 ± 65.7 vs 415.39 ± 74.02, p = 0.000) and girls (338.33 ± 63.33 vs 368.61 ± 75.45, p = 0.047). SUA was negatively correlated with BMD in all age groups of boys and in the 6-9 years group of girls (p<0.05). Multiple linear regression analysis showed that after controlling for other factors affecting BMD, SUA remained significantly negatively correlated with BMD Z-scores (p < 0.001).
SUA is negatively correlated with BMD in children with obesity and is an independent factor affecting BMD. It may serve as a potential predictor of BMD in children with obesity.
探讨肥胖儿童血清尿酸（SUA）水平与骨密度（BMD）之间的关系。
本研究纳入229名肥胖儿童，检测其血液中的SUA、空腹血糖（FPG）、糖化血红蛋白（HbAlc）、钙（Ca）、磷（P）、25-羟基维生素D（25(OH)D）及其他指标。在桡骨和尺骨处评估前臂远端骨密度。比较不同性别和年龄组这些指标的差异。
骨密度在性别和年龄组之间存在显著差异。6 - 9岁组男孩（-0.13±0.92 vs -1.27±0.62，p = 0.000）和女孩（0.68±0.96 vs -0.03±0.73，p = 0.001）的骨密度Z值均高于10 - 12岁组。6 - 9岁组男孩（345.9±65.7 vs 415.39±74.02，p = 0.000）和女孩（338.33±63.33 vs 368.61±75.45，p = 0.047）的血清SUA水平均低于10 - 12岁组。在所有年龄组男孩及6 - 9岁组女孩中，SUA与骨密度呈负相关（p<0.05）。多元线性回归分析显示，在控制其他影响骨密度的因素后，SUA仍与骨密度Z值呈显著负相关（p < 0.001）。
肥胖儿童的SUA与骨密度呈负相关，是影响骨密度的独立因素。它可能作为肥胖儿童骨密度的潜在预测指标。
