Correlation Analysis between Serum Uric Acid Levels and Bone Mineral Density in Children with Obesity.

PURPOSE

To investigate the relationship between serum uric acid (SUA) levels and bone mineral density (BMD) in children with obesity.

METHODS

229 children with obesity were included in the study, and their blood SUA, fasting plasma glucose (FPG), glycosylated hemoglobin (HbAlc), calcium (Ca), phosphorus (P), 25-hydroxyvitamin D (25(OH)D) and other indicators were measured. Distal forearm BMD was assessed at the radius and ulna. Differences in these indicators were compared across different genders and age groups.

RESULTS

BMD showed significant differences between genders and age groups. The BMD Z-score in the 6-9 years group was higher than that in the 10-12 years group for both boys (-0.13 ± 0.92 vs -1.27 ± 0.62, p = 0.000) and girls (0.68 ± 0.96 vs -0.03 ± 0.73, p = 0.001). Serum SUA levels in the 6-9 years group were lower than those in the 10-12 years group for both boys (345.9 ± 65.7 vs 415.39 ± 74.02, p = 0.000) and girls (338.33 ± 63.33 vs 368.61 ± 75.45, p = 0.047). SUA was negatively correlated with BMD in all age groups of boys and in the 6-9 years group of girls (p<0.05). Multiple linear regression analysis showed that after controlling for other factors affecting BMD, SUA remained significantly negatively correlated with BMD Z-scores (p < 0.001).

CONCLUSION

SUA is negatively correlated with BMD in children with obesity and is an independent factor affecting BMD. It may serve as a potential predictor of BMD in children with obesity.