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[2009年至2018年刚果民主共和国流感的流行病学、临床和病毒学特征]

[Epidemiological, clinical, and virological profile of influenza in the Democratic Republic of the Congo, from 2009 to 2018].

作者信息

Muhemedi Saleh, Lusamba Paul, Nkwembe Edith, Lubula Léopold, Manya Léonie, Babakazo Pélagie

机构信息

Ecole de Santé Publique de Kinshasa, Université de Kinshasa, Kinshasa, République démocratique du Congo.

Institut National des Recherches Biomédicales, Ministère de la Santé, Hygiène et Prévention, Kinshasa, République démocratique du Congo.

出版信息

Pan Afr Med J. 2025 Mar 10;50:68. doi: 10.11604/pamj.2025.50.68.33798. eCollection 2025.

DOI:10.11604/pamj.2025.50.68.33798
PMID:40486007
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12143314/
Abstract

INTRODUCTION

since 2007, the Democratic Republic of the Congo has implemented a sentinel influenza surveillance systems, operating across 11 healthcare facilities. These facilities collected oropharyngeal and nasopharyngeal samples from patients suspected of having influenza, based on case definitions. The collected samples were then sent to the national influenza laboratory at the INRB for analysis. This study describes the epidemiological, clinical, and virological profiles of these patients.

METHODS

we conducted a cross-sectional study based on a documentary review of notification forms of suspected influenza cases, from January 2009 to December 2018. The variables analyzed included sex, age, symptoms, sentinel site, patient category, identified viral type and subtype, and the period occurrence.

RESULTS

out of a total of 18,461 reported cases, 1,795 (9.7%) tested positive for the influenza virus. Children under five years old accounted for 53.1% of positive cases. Influenza type A was present in 68% of cases, while type B accounted for 31.5%. Positive SARI (Severe Acute Respiratory Infection) cases represented 21%, whereas positive ILI (Influenza-Like Illness) cases accounted for 79%. The vast majority of cases occurred during the rainy season.

CONCLUSION

this study enabled us to determine the burden of influenza among acute respiratory infections and the prevalence of circulating influenza viruses.

摘要

引言

自2007年以来,刚果民主共和国实施了哨点流感监测系统,该系统在11个医疗机构开展工作。这些机构根据病例定义,从疑似流感患者中采集口咽和鼻咽样本。然后将采集的样本送往国家生物医学研究所的国家流感实验室进行分析。本研究描述了这些患者的流行病学、临床和病毒学特征。

方法

我们基于对2009年1月至2018年12月疑似流感病例报告表的文献回顾,开展了一项横断面研究。分析的变量包括性别、年龄、症状、哨点、患者类别、鉴定出的病毒类型和亚型以及发病时期。

结果

在总共报告的18461例病例中,1795例(9.7%)流感病毒检测呈阳性。五岁以下儿童占阳性病例的53.1%。甲型流感占病例的68%,而乙型流感占31.5%。严重急性呼吸道感染(SARI)阳性病例占21%,而流感样疾病(ILI)阳性病例占79%。绝大多数病例发生在雨季。

结论

本研究使我们能够确定急性呼吸道感染中流感的负担以及流行流感病毒的流行情况。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff78/12143314/34a3695ca1f9/PAMJ-50-68-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff78/12143314/396783d10842/PAMJ-50-68-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff78/12143314/34a3695ca1f9/PAMJ-50-68-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff78/12143314/396783d10842/PAMJ-50-68-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff78/12143314/34a3695ca1f9/PAMJ-50-68-g002.jpg

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