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睡眠剥夺对年轻人脑雾、认知衰退和心血管风险的影响。

The Impact of Sleep Deprivation on Brain Fog, Cognitive Decline, and Cardiovascular Risk in Young Adults.

作者信息

Younas Aimen, Vayolipoyil Sarath, Raghib Shaheera, Bano Sher, Wandala Abali, Khan Azmir Ali, Amin Areej, Asim Khan Aima, Muhammad Ali Syed, Iqbal Javed, Umar Muhammad, Ul Ferdous Jannat, Zaidi Syeda Maryam Zehra

机构信息

Internal Medicine, Ayub Medical College, Abbottabad, PAK.

General Medicine, Scarborough General Hospital, York and Scarborough Teaching Hospitals NHS Foundation Trust, Scarborough, GBR.

出版信息

Cureus. 2025 May 8;17(5):e83757. doi: 10.7759/cureus.83757. eCollection 2025 May.

Abstract

Introduction Sleep deprivation is an escalating public health concern among young adults, as it impairs cognitive function and increases the risk of cardiovascular disease (CVD). Existing studies have linked chronic sleep deficiencies to mental confusion, reduced cognitive performance, and early signs of cognitive decline. Research also indicates that inadequate sleep contributes to metabolic dysregulation and autonomic system instability, both of which elevate cardiovascular risk. However, the overall effects of sleep deprivation on cognitive function and cardiovascular markers in young adults require further exploration. This study aims to examine the relationship between sleep deprivation, brain fog, early cognitive decline, and cardiovascular risk factors in this population. Methods This cross-sectional study involved 300 participants aged 18-30 from Pakistan and various other countries. Participants were selected using non-probability purposive sampling. Data were collected using four validated instruments: the Pittsburgh Sleep Quality Index, the Cognitive Failures Questionnaire, the Mini-Mental State Examination, and the Perceived Stress Scale. Data analysis was conducted using IBM SPSS Statistics for Windows, Version 26.0 (Released 2019; IBM Corp., Armonk, NY, USA), applying chi-square tests, independent sample t-tests, ANOVA, Pearson correlation, and logistic regression to assess associations between sleep deprivation, cognitive performance, and cardiovascular outcomes. Results Participants with shorter sleep durations had significantly higher scores in cognitive failures (p < 0.01) and perceived stress (p < 0.01). Poor sleep quality was associated with reduced cognitive performance (r = -0.114, p < 0.05), and it also increased the likelihood of developing cardiovascular risk factors. Participants with a family history of CVD exhibited significantly higher cognitive failure scores (t = 5.540, p < 0.001). Furthermore, a decline in sleep quality was associated with increased cardiovascular risk (B = 0.035, p = 0.019), although sleep disorders were not significantly influenced by sleep quality deterioration (B = 0.012, p = 0.400). Employment status and smoking habits were also found to impact both sleep quality and cognitive function (p < 0.01). Conclusions This study highlights the adverse impact of insufficient sleep on cognitive function and cardiovascular health in young adults aged 18-30. Poor sleep quality is associated with increased cognitive errors, heightened stress levels, and a greater risk of cardiovascular issues. These findings emphasize the importance of targeted health interventions aimed at improving sleep hygiene and lifestyle behaviors to reduce the risk of early cognitive decline and cardiovascular conditions. Future research should employ longitudinal designs and objective sleep tracking to strengthen causal inferences.

摘要

引言

睡眠剥夺是年轻成年人中日益严重的公共卫生问题,因为它会损害认知功能并增加心血管疾病(CVD)的风险。现有研究已将慢性睡眠不足与精神混乱、认知能力下降以及认知衰退的早期迹象联系起来。研究还表明,睡眠不足会导致代谢失调和自主神经系统不稳定,这两者都会增加心血管疾病风险。然而,睡眠剥夺对年轻成年人认知功能和心血管指标的总体影响仍需进一步探索。本研究旨在探讨该人群中睡眠剥夺、脑雾、早期认知衰退与心血管危险因素之间的关系。

方法

这项横断面研究涉及300名年龄在18至30岁之间的来自巴基斯坦及其他国家的参与者。参与者采用非概率目的抽样法选取。使用四种经过验证的工具收集数据:匹兹堡睡眠质量指数、认知失误问卷、简易精神状态检查表和感知压力量表。使用IBM SPSS Statistics for Windows,版本26.0(2019年发布;IBM公司,美国纽约州阿蒙克)进行数据分析,应用卡方检验、独立样本t检验、方差分析、皮尔逊相关性分析和逻辑回归来评估睡眠剥夺、认知表现和心血管结局之间的关联。

结果

睡眠时间较短的参与者在认知失误(p < 0.01)和感知压力(p < 0.01)方面得分显著更高。睡眠质量差与认知能力下降有关(r = -0.114,p < 0.05),并且还增加了患心血管危险因素的可能性。有心血管疾病家族史的参与者认知失误得分显著更高(t = 5.540,p < 0.001)。此外,睡眠质量下降与心血管疾病风险增加有关(B = 0.035,p = 0.019),尽管睡眠障碍并未受到睡眠质量恶化的显著影响(B = 0.012,p = 0.400)。就业状况和吸烟习惯也被发现会影响睡眠质量和认知功能(p < 0.01)。

结论

本研究强调了睡眠不足对18至30岁年轻成年人认知功能和心血管健康的不利影响。睡眠质量差与认知错误增加、压力水平升高以及心血管问题风险加大有关。这些发现强调了有针对性的健康干预措施的重要性,这些措施旨在改善睡眠卫生和生活方式行为,以降低早期认知衰退和心血管疾病的风险。未来的研究应采用纵向设计和客观的睡眠跟踪方法来加强因果推断。

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