双能X线吸收法（DEXA）与血清抗酒石酸酸性磷酸酶5b（TRAP-5b）在经典型失盐型先天性肾上腺皮质增生症患儿中的骨密度评估
Bone Mineral Density Assessment by Dual-Energy X-Ray Absorptiometry (DEXA) Versus Serum Tartrate-Resistant Acid Phosphatase 5b (TRAP-5b) in Children With Classic Salt-Losing Congenital Adrenal Hyperplasia.
作者信息
ElBakry Noura M, Khalf Asmaa, Ameen Mohamed, Mahgoob Mohamed
机构信息
Pediatric, Faculty of Medicine, Minia University, Minia, EGY.
Clinical Pathology, Faculty of Medicine, Minia University, Minia, EGY.
出版信息
Cureus. 2025 May 9;17(5):e83778. doi: 10.7759/cureus.83778. eCollection 2025 May.
UNLABELLED
Chronic glucocorticoid (cGC) therapy is a leading cause of drug-induced osteoporosis, often resulting in severe bone loss. Bone mineral density (BMD) is maintained by a dynamic balance between bone formation and resorption, regulated by various hormones, vitamin D, and cytokines. BMD is typically measured using dual-energy X-ray absorptiometry (DEXA). Tartrate-resistant acid phosphatase 5b (TRAP-5b) serves as a biomarker of bone resorption and is utilized to assess osteoclast activity.
OBJECTIVES
This study aimed to evaluate BMD by measuring serum TRAP-5b levels in patients with congenital adrenal hyperplasia (CAH) receiving steroid therapy.
METHODS
Forty patients with CAH underwent DEXA scans to assess BMD. Patients were then divided into two groups: one with normal BMD (n=14) and the other with abnormal BMD (n=26). Serum TRAP-5b levels were measured as a marker of bone turnover.
RESULTS
Children with CAH had significantly lower BMD in both the vertebrae and femoral neck. TRAP-5b levels were significantly higher in the abnormal BMD group (2.95 U/L) compared to the normal BMD group (p<0.001), indicating increased bone resorption in CAH.
CONCLUSIONS
Serum TRAP-5b activity may be a significant diagnostic and prognostic marker for bone disease in CAH.
未标注
长期糖皮质激素（cGC）治疗是药物性骨质疏松的主要原因，常导致严重的骨质流失。骨矿物质密度（BMD）通过骨形成与骨吸收之间的动态平衡来维持，这一平衡受多种激素、维生素D和细胞因子调节。BMD通常采用双能X线吸收法（DEXA）测量。抗酒石酸酸性磷酸酶5b（TRAP - 5b）作为骨吸收的生物标志物，用于评估破骨细胞活性。
目的
本研究旨在通过测量接受类固醇治疗的先天性肾上腺皮质增生症（CAH）患者血清TRAP - 5b水平来评估BMD。
方法
40例CAH患者接受DEXA扫描以评估BMD。然后将患者分为两组：一组BMD正常（n = 14），另一组BMD异常（n = 26）。测量血清TRAP - 5b水平作为骨转换的标志物。
结果
CAH患儿的腰椎和股骨颈BMD显著降低。与BMD正常组相比，BMD异常组的TRAP - 5b水平显著更高（2.95 U/L）（p < 0.001），表明CAH患者骨吸收增加。
结论
血清TRAP - 5b活性可能是CAH患者骨疾病的重要诊断和预后标志物。
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