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Synovial joints: The barometer of systemic inflammation.

作者信息

Pan Jie, Liu Qianqian, Sun Yang

机构信息

State Key Laboratory of Pharmaceutical Biotechnology and Nanjing Drum Tower Hospital the Affiliated Hospital of Nanjing University Medical School, School of Life Sciences, Nanjing University, Nanjing 210023, China.

Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, the Key Laboratory of Anti-inflammatory of Immune Medicines, Ministry of Education, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei 230032, China.

出版信息

Acta Pharm Sin B. 2025 Apr;15(4):2287-2289. doi: 10.1016/j.apsb.2024.12.025. Epub 2024 Dec 26.

DOI:10.1016/j.apsb.2024.12.025
PMID:40486842
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12138111/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/def1/12138111/b7a115ccf82a/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/def1/12138111/b7a115ccf82a/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/def1/12138111/b7a115ccf82a/gr1.jpg

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Synovial joints: The barometer of systemic inflammation.滑膜关节：全身炎症的晴雨表。
Acta Pharm Sin B. 2025 Apr;15(4):2287-2289. doi: 10.1016/j.apsb.2024.12.025. Epub 2024 Dec 26.
2
Macrophages and nociceptor neurons form a sentinel unit around fenestrated capillaries to defend the synovium from circulating immune challenge.巨噬细胞和伤害感受器神经元围绕有孔毛细血管形成一个哨兵单元，以保护滑膜免受循环免疫挑战。
Nat Immunol. 2024 Dec;25(12):2270-2283. doi: 10.1038/s41590-024-02011-8. Epub 2024 Nov 25.
3
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本文引用的文献

1
Macrophages and nociceptor neurons form a sentinel unit around fenestrated capillaries to defend the synovium from circulating immune challenge.巨噬细胞和伤害感受器神经元围绕有孔毛细血管形成一个哨兵单元，以保护滑膜免受循环免疫挑战。
Nat Immunol. 2024 Dec;25(12):2270-2283. doi: 10.1038/s41590-024-02011-8. Epub 2024 Nov 25.
2
TLR7/8 Activation in Immune Cells and Muscle by RNA-Containing Immune Complexes: Role in Inflammation and the Pathogenesis of Myositis.含RNA免疫复合物在免疫细胞和肌肉中激活TLR7/8：在炎症和肌炎发病机制中的作用
Arthritis Rheumatol. 2025 Feb;77(2):190-201. doi: 10.1002/art.42989. Epub 2024 Nov 4.
3
Tofacitinib therapy in systemic lupus erythematosus with arthritis: a retrospective study.
托法替尼治疗关节炎系统性红斑狼疮：一项回顾性研究。
Clin Rheumatol. 2024 Oct;43(10):3139-3145. doi: 10.1007/s10067-024-07103-2. Epub 2024 Aug 13.
4
Lupus IgA1 autoantibodies synergize with IgG to enhance plasmacytoid dendritic cell responses to RNA-containing immune complexes.狼疮 IgA1 自身抗体与 IgG 协同作用增强浆细胞样树突状细胞对含 RNA 免疫复合物的反应。
Sci Transl Med. 2024 Jul 3;16(754):eadl3848. doi: 10.1126/scitranslmed.adl3848.
5
CGRP sensory neurons promote tissue healing via neutrophils and macrophages.降钙素基因相关肽感觉神经元通过中性粒细胞和巨噬细胞促进组织愈合。
Nature. 2024 Apr;628(8008):604-611. doi: 10.1038/s41586-024-07237-y. Epub 2024 Mar 27.
6
Nociceptor neurons affect cancer immunosurveillance.伤害感受器神经元影响癌症免疫监视。
Nature. 2022 Nov;611(7935):405-412. doi: 10.1038/s41586-022-05374-w. Epub 2022 Nov 2.
7
Targeting macrophagic SHP2 for ameliorating osteoarthritis TLR signaling.靶向巨噬细胞中的SHP2以改善骨关节炎的TLR信号传导
Acta Pharm Sin B. 2022 Jul;12(7):3073-3084. doi: 10.1016/j.apsb.2022.02.010. Epub 2022 Feb 17.
8
Enteric Pathogens and Reactive Arthritis: Systematic Review and Meta-Analyses of Pathogen-Associated Reactive Arthritis.肠道病原体与反应性关节炎：病原体相关性反应性关节炎的系统评价与荟萃分析
Foodborne Pathog Dis. 2021 Sep;18(9):627-639. doi: 10.1089/fpd.2020.2910. Epub 2021 Jul 13.
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Layered dissolving microneedles as a need-based delivery system to simultaneously alleviate skin and joint lesions in psoriatic arthritis.分层溶解微针作为一种按需给药系统，可同时缓解银屑病关节炎的皮肤和关节损伤。
Acta Pharm Sin B. 2021 Feb;11(2):505-519. doi: 10.1016/j.apsb.2020.08.008. Epub 2020 Aug 28.
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Notch signalling drives synovial fibroblast identity and arthritis pathology.Notch 信号通路驱动滑膜成纤维细胞的特性和关节炎病理。
Nature. 2020 Jun;582(7811):259-264. doi: 10.1038/s41586-020-2222-z. Epub 2020 Apr 22.