2型糖尿病患者血糖在目标范围内的时间与冠状动脉疾病严重程度的关系：一项横断面研究。
Relation of time in range to severity of coronary artery disease in patients with type 2 diabetes: A cross-sectional study.
作者信息
Ma Weiguo, Li Jinfeng, Shao Xiaojuan, Yin Xiaohong, Xie Chuanqing, Wang Fenfen, Li Ya
机构信息
Department of Endocrinology, The First Affiliated Hospital of Xi'an Medical University, Xi'an, 710077, China.
Department of Endocrinology, The First Affiliated Hospital of Xi'an Medical University, 48 Fenghao West Road, Lianhu District, Xi'an, 710077, China.
出版信息
Open Med (Wars). 2025 Jun 4;20(1):20251158. doi: 10.1515/med-2025-1158. eCollection 2025.
BACKGROUND
Despite the high prevalence and serious clinical implications of coronary artery disease (CAD) in patients with type 2 diabetes mellitus (T2DM), the relationship between glycemic control and CAD is usually overlooked. This study aimed to explore the relationship between time in range (TIR), a surrogate marker for glycemic control, and CAD in patients with T2DM.
METHODS
Overall, 334 patients with T2DM were included and analyzed in this cross-sectional study. The presence of CAD was determined angiographically and the Gensini score was applied to evaluate CAD severity. TIR was calculated from sensor glucose from continuous glucose monitoring. Multivariable-adjusted logistic regression analysis was used to evaluate the relationship between TIR and CAD presence.
RESULTS
T2DM with CAD had significantly lower TIR than those without (75.68 ± 13.74 vs 66.12 ± 11.87, < 0.01). Moreover, TIR was correlated with CAD severity as indicated by the Gensini score. Multivariable-adjusted logistic regression analysis indicated that a higher TIR was an independent protective factor for CAD in patients with T2DM (OR = 0.919, 95% CI: 0.896-0.942).
CONCLUSION
TIR is significantly and independently related to CAD severity in T2DM patients. Thus, TIR could be a promising biomarker for the noninvasive assessment of CAD presence and severity in T2DM.
背景
尽管2型糖尿病（T2DM）患者中冠状动脉疾病（CAD）的患病率很高且具有严重的临床意义，但血糖控制与CAD之间的关系通常被忽视。本研究旨在探讨血糖控制的替代指标——血糖达标时间（TIR）与T2DM患者CAD之间的关系。
方法
在这项横断面研究中，共纳入并分析了334例T2DM患者。通过血管造影确定CAD的存在，并应用Gensini评分评估CAD的严重程度。TIR由连续血糖监测的传感器葡萄糖数据计算得出。采用多变量调整的逻辑回归分析来评估TIR与CAD存在之间的关系。
结果
患有CAD的T2DM患者的TIR显著低于无CAD的患者（75.68±13.74 vs 66.12±11.87，<0.01）。此外，TIR与Gensini评分所示的CAD严重程度相关。多变量调整的逻辑回归分析表明，较高的TIR是T2DM患者CAD的独立保护因素（OR = 0.919，95%CI：0.896 - 0.942）。
结论
TIR与T2DM患者的CAD严重程度显著且独立相关。因此，TIR可能是用于无创评估T2DM患者CAD存在和严重程度的有前景的生物标志物。
Zotero 插件