Dina Elena, Pallarés Martí Beatriz, Filomena Vincenzo, Prenafeta Moreno Mario, Díaz Argüello Juan José, Blázquez Mañá Carmen María, Sánchez Fernández Joël, Escamilla Carpintero Yolanda
Otorhinolaryngology Department, Parc Tauli Health Corporation Consortium, Parc Tauli 1, Sabadell 08208, Spain.
Neuroradiology Division, Diagnostic Imaging Department, Parc Tauli Health Corporation Consortium, Parc Tauli 1, Sabadell 08208, Spain.
Case Rep Otolaryngol. 2025 May 30;2025:8268690. doi: 10.1155/crot/8268690. eCollection 2025.
A 68-year-old man previously treated for a large laryngeal neoplasm (pT4 pN0 squamous cell carcinoma) developed osteomyelitis of the medial third of the right clavicle with the formation of a fistula between the sternoclavicular joint and tracheal wall near the tracheostomy border. The clinical course was tedious, required prolonged antibiotic trials, and extended surgical bone resection to control the infection. The final outcome was favorable with wound closure although the patient was left with permanent limitation of shoulder abduction (his shoulder mobility had been normal prior to this process). Histopathological examination of the resected bone suggested a diagnosis of both osteoradionecrosis and osteomyelitis. Indeed, differential diagnosis between these two entities can be challenging after radiotherapy. Here, we present a review of the relevant academic literature and discuss the therapeutic options.
一名68岁男性曾因大型喉肿瘤(pT4 pN0鳞状细胞癌)接受治疗,现发生右锁骨内侧三分之一骨髓炎,在胸骨柄关节与气管造口边缘附近的气管壁之间形成了瘘管。临床病程冗长,需要长时间的抗生素试验,并进行扩大的手术骨切除以控制感染。尽管患者肩部外展永久受限(在此过程之前其肩部活动正常),但最终伤口愈合良好。切除骨的组织病理学检查提示诊断为放射性骨坏死和骨髓炎。实际上,放疗后这两种疾病的鉴别诊断可能具有挑战性。在此,我们对相关学术文献进行综述并讨论治疗选择。