Deysine M, Katzka D, Rosario E
Am J Gastroenterol. 1977 Feb;67(2):152-6.
Rats, weighing 125-150 gm., were restrained under a tight wire screen for one hour at 20degrees C and another hour at 4degrees C of ambient temperature. Animals receiving no infusions, or those receiving an intravenous solution of normal saline, developed 16 +/- 3 S.D. bleeding areas in their gastric mucosa. In contrast, in animals exposed to the same degree of stress who received intravenous hyperalimentation, the number of gastric stress bleeding areas counted was 4 +/- 2 S.D. These results demonstrate that the delivery of calories and protein in the form if intravenous hyperalimentation can significantly reduce the incidence of gastric stress bleeding in an experimental model (P less than .001).
体重为125 - 150克的大鼠，在20摄氏度的环境温度下被紧缚于铁丝筛下一小时，然后在4摄氏度的环境温度下再缚一小时。未接受输液的动物，或接受生理盐水静脉溶液的动物，胃黏膜出现16±3标准差的出血区域。相比之下，在遭受同等程度应激且接受静脉高营养的动物中，所计数的胃应激性出血区域数量为4±2标准差。这些结果表明，以静脉高营养的形式提供热量和蛋白质，可在实验模型中显著降低胃应激性出血的发生率（P<0.001）。
