Park Seon Young, Seo Seongwon, Kim Ji Hyung
Laboratory of Aquatic Biomedicine, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul, Republic of Korea.
Veterinary Drugs and Biologics Division, Animal and Plant Quarantine Agency, Gimcheon, Republic of Korea.
Front Vet Sci. 2025 May 23;12:1466437. doi: 10.3389/fvets.2025.1466437. eCollection 2025.
/ complex (SBSEC) comprises eight (sub)species, with several opportunistic pathogenic members. These SBSEC species are associated with metabolic disorders in ruminants, resulting in economic losses to the global livestock industry. Moreover, the emergence of antimicrobial resistance (AMR) in SBSEC strains, particularly against commonly used antibiotics, poses serious concerns to the livestock industry. Therefore, alternative approaches to control SBSEC infections have garnered increased attention, and several applications of bacteriophages (phages) have exhibited promising results. Research on SBSEC and their phages has been limited, particularly in livestock production. However, advancements in molecular techniques and a growing interest in alternative strategies to combat AMR have brought SBSEC and their phages into the spotlight. Molecular techniques, such as whole-genome sequencing, have revolutionized the accurate identification and classification of SBSEC, resulting in the elucidation of their ecological and pathogenic roles. SBSEC-infecting phages exhibit remarkable diversity and potential as biocontrol agents, with phage-derived endolysins offering targeted regulation of the SBSEC populations in the rumen. Despite recent achievements, knowledge gaps exist in understanding phage-host interactions and evaluating the efficacy of phage in biologically relevant models, warranting the integration of , , and approaches. Here, we comprehensively review the current knowledge regarding the taxonomy, AMR characteristics, and diversity of SBSEC, and the potential of SBSEC-specific phages, focusing on recent advances in basic research and biotechnological applications in ruminants. Harnessing the potential of SBSEC-specific phages and their derivatives as innovative solutions should help promote overall animal health and the production of antibiotic-free livestock.
复杂（小肠结肠炎耶尔森菌复合群，SBSEC）包括八个（亚）种，其中有几个是机会致病菌成员。这些SBSEC菌种与反刍动物的代谢紊乱有关，给全球畜牧业造成经济损失。此外，SBSEC菌株中出现的抗菌药物耐药性（AMR），尤其是对常用抗生素的耐药性，给畜牧业带来了严重担忧。因此，控制SBSEC感染的替代方法受到了越来越多的关注，噬菌体（phages）的几种应用已显示出有希望的结果。对SBSEC及其噬菌体的研究一直有限，特别是在畜牧生产中。然而，分子技术的进步以及对对抗AMR替代策略的兴趣日益浓厚，使SBSEC及其噬菌体成为焦点。全基因组测序等分子技术彻底改变了SBSEC的准确鉴定和分类，从而阐明了它们的生态和致病作用。感染SBSEC的噬菌体作为生物防治剂表现出显著的多样性和潜力，噬菌体衍生的内溶素可对瘤胃中的SBSEC种群进行靶向调控。尽管最近取得了一些成就，但在理解噬菌体-宿主相互作用以及评估噬菌体在生物学相关模型中的功效方面仍存在知识空白，这就需要整合 、 和 方法。在这里，我们全面回顾了关于SBSEC的分类学、AMR特征和多样性以及SBSEC特异性噬菌体潜力的现有知识，重点关注反刍动物基础研究和生物技术应用的最新进展。利用SBSEC特异性噬菌体及其衍生物的潜力作为创新解决方案，应有助于促进动物整体健康和无抗生素家畜的生产。
