Liu Huazhen, Wang Jingjing, Zhao Chenyang, Zhang Rui, Wang Ming, Jiang Yuxin, Sun Desheng, Hou Yanglong, Yang Meng
Department of Ultrasound, State Key Laboratory of Complex Severe and Rare Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shuaifuyuan No.1, Dongcheng District, Beijing 100730, China.
School of Materials, Shenzhen Campus of Sun Yat-Sen University, Yiheyuan Road No.5, Haidian District, Beijing 100871, China.
iScience. 2025 May 3;28(6):112576. doi: 10.1016/j.isci.2025.112576. eCollection 2025 Jun 20.
Rheumatoid arthritis (RA) is characterized by poor oxygen supply and overproduction of reactive oxygen species (ROS), thereby exacerbating synovial inflammation. We synthesized MPDA@CeO nanoparticles (NPs) by incorporating mesoporous polydopamine (MPDA) NPs and CeO for photoacoustic imaging (PAI)-guided synergistic light-controlled PTT/oxygen-boosting/ROS-eliminating therapy. Upon irradiation with a near-infrared (NIR) laser, MPDA@CeO NPs trigger photothermal conversion to eradicate inflammatory cells and release CeO, which have a catalytic activity to eliminate ROS and release oxygen. The oxygen-release and ROS-depleting efficiency was simultaneously augmented by heat to further combat the harmful environment of inflammation. We validated the therapeutic effect of MPDA@CeO and . We further applied multiwavelength PAI to observe the distribution of NPs and the change in oxygen saturation during the treatment process . The study highlights the therapeutic value of MPDA@CeO in inhibiting arthritis in RA through imaging-guided synergistic therapy.
类风湿性关节炎（RA）的特征是供氧不足和活性氧（ROS）过度产生，从而加剧滑膜炎症。我们通过将介孔聚多巴胺（MPDA）纳米颗粒（NPs）和CeO结合，合成了MPDA@CeO纳米颗粒，用于光声成像（PAI）引导的协同光控光热疗法（PTT）/增氧/ROS消除治疗。在用近红外（NIR）激光照射时，MPDA@CeO纳米颗粒触发光热转换以根除炎症细胞并释放CeO，CeO具有消除ROS和释放氧气的催化活性。通过加热同时提高氧释放和ROS消耗效率，以进一步对抗炎症的有害环境。我们验证了MPDA@CeO的治疗效果。我们进一步应用多波长PAI来观察纳米颗粒的分布以及治疗过程中氧饱和度的变化。该研究突出了MPDA@CeO通过成像引导的协同治疗在抑制RA中的关节炎方面的治疗价值。
