Snega Priya P, Pratiksha Nandhini P, Arockiaraj Jesu
Toxicology and Pharmacology Laboratory, Department of Biotechnology, SRM Institute of Science and Technology, Faculty of Science and Humanities, Kattankulatur, 603203, Chengalpattu District, Tamil Nadu, India.
Toxicology and Pharmacology Laboratory, Department of Biotechnology, SRM Institute of Science and Technology, Faculty of Science and Humanities, Kattankulatur, 603203, Chengalpattu District, Tamil Nadu, India.
Environ Res. 2023 Nov 15;237(Pt 2):117103. doi: 10.1016/j.envres.2023.117103. Epub 2023 Sep 7.
A significant problem that has an impact on community wellbeing is environmental pollution. Environmental pollution due to air, water, or soil pollutants might pose a severe risk to global health, necessitating intense scientific effort. Osteoporosis is a common chronic condition with substantial clinical implications on mortality, morbidity, and quality of life. It is closely linked to bone fractures. Worldwide, osteoporosis affects around 200 million people, and every year, there are almost 9 million fractures. There is evidence that certain environmental factors may increase the risk of osteoporosis in addition to traditional risk factors. It is crucial to understand the molecular mechanisms at play because there is a connection between osteoporosis and exposure to environmental pollutants such as heavy metals, air pollutants, endocrine disruptors, metal ions and trace elements. Hence, in this scoping review, we explore potential explanations for the link between pollutants and bone deterioration through deep insights into molecular pathways. Understanding and recognizing these pollutants as modifiable risk factors for osteoporosis would possibly help to enhance environmental policy thereby aiding in the improvement of bone health and improving patient quality of life.
环境污染是一个影响社区福祉的重大问题。空气、水或土壤污染物造成的环境污染可能对全球健康构成严重风险，需要进行大量科学研究。骨质疏松症是一种常见的慢性病，对死亡率、发病率和生活质量具有重大临床影响。它与骨折密切相关。在全球范围内，骨质疏松症影响着约2亿人，每年有近900万例骨折。有证据表明，除了传统风险因素外，某些环境因素可能会增加患骨质疏松症的风险。了解其中的分子机制至关重要，因为骨质疏松症与接触重金属、空气污染物、内分泌干扰物、金属离子和微量元素等环境污染物之间存在关联。因此，在本范围综述中，我们通过深入洞察分子途径，探索污染物与骨质恶化之间联系的潜在解释。将这些污染物理解并认识为骨质疏松症的可改变风险因素，可能有助于加强环境政策，从而有助于改善骨骼健康并提高患者生活质量。
