Chai Xiuyun, Nawar Mohamed F, Lüthi Matthias, Zingg Ronald, Kottler Christian, Türler Andreas
Department of Chemistry, Biochemistry, and Pharmaceutical Sciences, University of Bern, 3012 Bern, Switzerland.
Federal Institute of Metrology, METAS, 3003 Bern-Wabern, Switzerland.
J Radioanal Nucl Chem. 2025;334(5):3359-3366. doi: 10.1007/s10967-025-10092-4. Epub 2025 Apr 19.
True theranostic radionuclide pairs are gaining interest in nuclear medicine. However, their application is limited due to their reduced availability. Sc is a promising therapeutic partner to the diagnostic Sc and Sc due to its ideal half-life and beta energy. This study attempted to develop a dry, gas-solid phase separation of non-carrier-added radioscandium from macro amounts of titanium. The results showed a 99.9% release of Sc from Ti foil of 50 μm thickness at 1100 °C in vacuum. Furthermore, a Monte Carlo model was developed to describe the release of Sc from Ti as a function of temperature and foil thickness. With this model the desorption energy of Sc from Ti surfaces was determined to be 390 ± 5 kJ/mol in excellent agreement with theoretical predictions. In an attempt to recover the evaporated Sc on a cold finger, highest overall yields of 65% were observed for gold surfaces. For other catcher materials such as Ti, Ta, and brass significantly lower overall yields between 27 and 47% were determined. Furthermore, it was not possible to quantitatively remove the Sc from the Au catcher, even when washing with concentrated acids. Attempts to increase the release of scandium from thick, sintered Ti samples failed to show an improvement over solid titanium.
真正的治疗诊断放射性核素对在核医学领域正受到越来越多的关注。然而，由于其可获得性降低，它们的应用受到限制。钪（Sc）因其理想的半衰期和β能量，是诊断性钪的一种有前景的治疗伙伴。本研究试图开发一种从大量钛中干式气固分离无载体添加放射性钪的方法。结果表明，在1100℃真空条件下，50μm厚的钛箔中钪的释放率达到99.9%。此外，还开发了一个蒙特卡罗模型来描述钪从钛中的释放与温度和箔厚度的函数关系。利用该模型，确定钪从钛表面的解吸能为390±5kJ/mol，与理论预测结果非常吻合。为了在冷阱上回收蒸发的钪，观察到金表面的最高总产率为65%。对于其他捕集材料，如钛、钽和黄铜，总产率显著较低，在27%至47%之间。此外，即使使用浓酸洗涤，也无法从金捕集器中定量去除钪。试图提高厚烧结钛样品中钪的释放率，但未显示出比固态钛有任何改善。
