Khanal Sonali, Thakur Pratibha, Sharma Aman, Kumar Anand, Pillai Manjusha, Kumar Deepak, Kumar Arun, Verma Rachna, Tapwal Ashwani, Kumar Dinesh, Kumar Vinod, Bala Asis
School of Bioengineering and Food Technology, Shoolini University of Biotechnology and Management Sciences, Solan, 173229 India.
ICFRE-Himalayan Forest Research Institute, Shimla, 171013 India.
3 Biotech. 2025 Jul;15(7):203. doi: 10.1007/s13205-025-04353-y. Epub 2025 Jun 7.
(Reishi), a valued medicinal fungus used in traditional medicine for over 2000 years, has sparked widespread scientific attention due to its extensive range of bioactive ingredients and therapeutic promise in modern medicine. This study presents a detailed and up-to-date examination of primary bioactive components, which include polysaccharides, triterpenoids, meroterpenoids, nucleotides, proteins, alkaloids, and sesquiterpenoids. These chemical components show a wide range of pharmacological effects, including immune modulation, cancer suppression, and neuroprotection. The review also gives insight on developing and underexplored therapeutic areas, such as the mushroom's antiviral properties particularly its anti-HIV potential as well as its anti-fibrotic, neuropharmacological, and anti-aging benefits. By combining traditional therapeutic knowledge with modern biomedical innovation, is positioned as a viable natural resource for solving modern health issues. Continued study is required to understand the molecular processes that underpin its many effects and to assist its incorporation into evidence-based medicinal applications. It subsequently emphasizes and thoroughly examines bioactive components, as well as insights into its rising role in healthcare, combining traditional knowledge with recent biological achievements.
灵芝，一种在传统医学中使用了两千多年的珍贵药用真菌，因其广泛的生物活性成分和在现代医学中的治疗前景而引发了广泛的科学关注。本研究对其主要生物活性成分进行了详细且最新的考察，这些成分包括多糖、三萜类化合物、半萜类化合物、核苷酸、蛋白质、生物碱和倍半萜类化合物。这些化学成分具有广泛的药理作用，包括免疫调节、抗癌和神经保护。该综述还深入探讨了其尚未充分开发的治疗领域，例如该蘑菇的抗病毒特性，尤其是其抗艾滋病毒的潜力，以及其抗纤维化、神经药理学和抗衰老益处。通过将传统治疗知识与现代生物医学创新相结合，灵芝被定位为解决现代健康问题的一种可行自然资源。需要持续研究以了解其多种作用背后的分子过程，并帮助将其纳入循证医学应用。随后，本文强调并全面审视了灵芝的生物活性成分，以及其在医疗保健中日益重要的作用，将传统知识与最新生物学成果相结合。
