Uman S J, Johnson C E, Beirne G J, Kunin C M
Am J Med. 1977 May;62(5):667-71. doi: 10.1016/0002-9343(77)90868-3.
Infections commonly occur in patients undergoing dialysis and have been related to diminished host resistance of uremic patients, the arteriovenous fistulas and bacteriologic contamination of dialysis fluids. The occurrence of four cases of bacteremia due to Pseudomonas, three of which were type 7, and the presence of this serotype in the dialysis fluids suggested an important association between infection and growth of bacteria in the fluids. Attempts to reduce levels of bacteria in the dialysis fluid were unsuccessful using dialysate free of glucose in clinical trial, despite in vitro studies demonstrating poor growth of Pseudomonas in this medium. A filter placed with the recirculating system was only partially successful. The second paper of this series traces the portal of entry of bacteria from dialysate to the blood through reutilized coils.
感染在接受透析的患者中很常见，并且与尿毒症患者宿主抵抗力下降、动静脉瘘以及透析液的细菌污染有关。出现了4例由铜绿假单胞菌引起的菌血症病例，其中3例为7型，并且该血清型存在于透析液中，这表明感染与透析液中细菌生长之间存在重要关联。在临床试验中，使用不含葡萄糖的透析液试图降低透析液中的细菌水平未成功，尽管体外研究表明铜绿假单胞菌在这种培养基中生长不佳。在循环系统中放置过滤器仅取得了部分成功。本系列的第二篇论文追踪了细菌从透析液通过再利用的盘管进入血液的途径。
