Jiang Yue, Xu Shao-Hua, Han Li, Lu Na, Huang Shuai, Wang Lei
Department of Ultrasound, The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital), Suzhou 215000, Jiangsu Province, China.
Department of Ultrasound, Shanghai Jiao Tong University School of Medicine Suzhou Jiulong Hospital, Suzhou 215000, Jiangsu Province, China.
World J Gastrointest Oncol. 2025 May 15;17(5):104194. doi: 10.4251/wjgo.v17.i5.104194.
Gastrointestinal dual-contrast ultrasonography (DCUS) is characterized by its high resolution, sensitivity, and specificity.
To determine the accuracy of DCUS in predicting lymph node metastasis in middle-aged and elderly patients with gastric cancer (GC).
A total of 100 middle-aged and elderly patients with GC admitted to the Fourth Affiliated Hospital of Soochow University (Dushu Lake Hospital, Suzhou, China) between April 2022 and April 2024 were selected. The baseline data and lymph node metastasis status were collected. DCUS combined with intravenous contrast technology was used to calculate the enhancement time (ET), time to peak (TTP), and slope of the ascending branch wash-in rate (WIR). These indicators were used in assessing lymph node metastasis in patients with GC.
Among 100 middle-aged and elderly patients with GC, 35 (35.00%) had lymph node metastases. GC patients with lymph node metastasis had a higher proportion of stage II TNM classification and higher WIR values than those without lymph node metastasis. The ET and TTP values were lower in patients with lymph node metastases, and all differences were statistically significant ( < 0.05). The area under the curve values for ET, TTP, WIR, and combined diagnosis of GC lymph node metastasis using DCUS were all > 0.7. Optimal assessment was achieved when the cutoff values for ET, TTP, and WIR were set at 16.32 seconds, 10.67 seconds, and 7.02, respectively.
DCUS-mediated assessment of ET, TTP, and WIR can effectively predict and evaluate lymph node metastasis status in patients with GC, with higher sensitivity when used in combination.
胃肠道双对比超声检查（DCUS）具有高分辨率、高灵敏度和高特异性的特点。
确定DCUS在预测中老年胃癌（GC）患者淋巴结转移中的准确性。
选取2022年4月至2024年4月期间苏州大学第四附属医院（中国苏州独墅湖医院）收治的100例中老年GC患者。收集基线数据和淋巴结转移状态。采用DCUS联合静脉造影技术计算增强时间（ET）、达峰时间（TTP）和上升支洗入率（WIR）斜率。这些指标用于评估GC患者的淋巴结转移情况。
100例中老年GC患者中，35例（35.00%）发生淋巴结转移。有淋巴结转移的GC患者Ⅱ期TNM分类比例和WIR值高于无淋巴结转移者。有淋巴结转移患者的ET和TTP值较低，所有差异均有统计学意义（<0.05）。DCUS对GC淋巴结转移的ET、TTP、WIR及联合诊断的曲线下面积值均>0.7。当ET、TTP和WIR的截断值分别设定为16.32秒、10.67秒和7.02时，可实现最佳评估。
DCUS介导的ET、TTP和WIR评估可有效预测和评估GC患者的淋巴结转移状态，联合使用时灵敏度更高。
