Banciu T, Arcan P, Stroe A
Med Interne. 1985 Jul-Sep;23(3):177-83.
This paper deals with the influencing of the imbalance of humoral and cellular immunity in chronic active liver disease (CALD) due to prolonged administration of continuous corticotherapy in moderate doses. This paper presents a controlled study carried out in 30 patients with CALD of whom 15 received corticotherapy, while the other 15 only a conventional hepatotropic treatment for a year. The results obtained show, beside a clinical and biological improvement, a positive influence on the immune parameters with a tendency of restoration of immune homeostasis, i.e., an increase of the T total and T1 (suppressing/cytotoxic) lymphocytes in the peripheral blood, with the concomitant decrease of IgG, IgM and circulating immune complexes (CIC). In the control group the changes were insignificant, but sometimes an aggravation of the immune disturbances could be observed. This study confirms the favourable effect of prolonged corticotherapy in CALD and argues for its immune-modulating action.
本文探讨了中度剂量持续皮质激素治疗时间过长对慢性活动性肝病（CALD）体液免疫和细胞免疫失衡的影响。本文介绍了一项对照研究，该研究对30例CALD患者进行，其中15例接受皮质激素治疗，另外15例仅接受常规保肝治疗，为期一年。获得的结果显示，除了临床和生物学改善外，对免疫参数有积极影响，具有免疫稳态恢复的趋势，即外周血中T总淋巴细胞和T1（抑制/细胞毒性）淋巴细胞增加，同时IgG、IgM和循环免疫复合物（CIC）减少。在对照组中，变化不显著，但有时可观察到免疫紊乱加重。本研究证实了长期皮质激素治疗对CALD的有利作用，并支持其免疫调节作用。
