慢性活动性肝病中抑制性T细胞功能丧失及循环免疫复合物
Loss of suppressor T cell function and circulating immune complexes in chronic active liver diseases.
作者信息
Hotta R, Kuriki J, Kakumu S
出版信息
Clin Exp Immunol. 1981 Nov;46(2):375-81.
Suppressor T cell function is decreased in patients with chronic active liver diseases (CALD). To account for the alterations, we examined the effect of sera of patients with various liver diseases on concanavalin A (Con A) induced suppressor T cell activity of normal individuals. The suppressor T cell activity was inhibited by heat-inactivated serum pretreatment in 13 of 27 cases of patients with CALD and in five of 11 cases of patients with acute viral hepatitis, whereas only two sera of 18 patients with other liver diseases affected suppressor cell activity. Using a 125I-C1q-binding test, a significant correlation (P less than 0.01) was detected between the degree of inhibition in the development of suppressor T cells and the level of circulating immune complexes in the sera of CALD patients. The blocking effect of patients' sera disappeared when the immune complexes were removed with polyethylene glycol. These data suggest that circulating immune complexes modulate cellular immunity in patients with CALD by influencing the suppressor T cell function.
慢性活动性肝病（CALD）患者的抑制性T细胞功能降低。为了解释这些变化，我们检测了各种肝病患者的血清对正常个体伴刀豆球蛋白A（Con A）诱导的抑制性T细胞活性的影响。27例CALD患者中有13例以及11例急性病毒性肝炎患者中有5例，其抑制性T细胞活性受到热灭活血清预处理的抑制，而18例其他肝病患者中只有2例血清影响抑制性细胞活性。通过125I-C1q结合试验，在CALD患者血清中，抑制性T细胞发育的抑制程度与循环免疫复合物水平之间检测到显著相关性（P小于0.01）。当用聚乙二醇去除免疫复合物时，患者血清的阻断作用消失。这些数据表明，循环免疫复合物通过影响抑制性T细胞功能来调节CALD患者的细胞免疫。
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