Nichifor E, Balea M, Rusu G, Melencu M, Ghiordănescu N, Cristescu I, Dovlete C, Sonoc S
Med Interne. 1985 Jul-Sep;23(3):229-37.
The study was carried out in an attempt to explain the familial character of endemic Balkan nephropathy and of agglomeration of cases in certain households and in the ascendency of certain families. The hypotheses of a genetic disease or that of an infectious etiology have been taken into consideration in previous studies - by chromosomal analyses and statistical-mathematic tests of contagiousness - without being able to find arguments in support of one or the other hypotheses. This study brings important elements in favour of the possible role of ecologic factors and mainly of the hydrictoxic one, in the determination of the familial agglomerations in endemic nephropathy. Thus using radionuclear determination methods, we could demonstrate in a locality of the endemic area that around the water sources with high content of nephrotoxic oligoelements (cadmium, chromium, manganese, cobalt) there are more diseased families than around water sources poorer in these oligoelements.
开展这项研究是为了解释地方性巴尔干肾病的家族特征、某些家庭中病例的聚集情况以及某些家族的优势地位。先前的研究通过染色体分析和传染性的统计数学测试，考虑了遗传疾病假说或感染病因假说，但未能找到支持其中任何一种假说的论据。这项研究提供了重要证据，支持生态因素尤其是水毒性因素在地方性肾病家族聚集现象的决定中可能发挥的作用。因此，通过放射性核素测定方法，我们能够证实在地方性病区的一个地方，富含肾毒性微量元素（镉、铬、锰、钴）的水源周围患病家庭比这些微量元素含量较低的水源周围更多。
