Tsoneva M, Dimitrov Ts, Toncheva D
Vutr Boles. 1985;24(5):61-6.
Twenty clinically healthy relatives were studied of patients with Balkan endemic nephropathy via high resolutive chromosome analysis. Dynamic deviations in G-band structure of third chromosome was established in 10 of the subjects studied, namely--shortening of the band 3q25 and a faster fusion of subbands 3q26.1 and 3q26.3, not corresponding to the stage of chromosomal contraction. A complete coincidence was obtained between the carriership if marker chromosome A3 and the data from the biopsy studies, revealing initial morphological changes in the kidney, characteristic for Balkan endemic nephropathy.
通过高分辨率染色体分析，对20名巴尔干地方性肾病患者的临床健康亲属进行了研究。在所研究的10名受试者中，发现第三条染色体的G带结构存在动态偏差，即3q25带缩短以及3q26.1和3q26.3亚带融合加快，这与染色体收缩阶段不符。标记染色体A3的携带情况与活检研究数据完全吻合，活检研究揭示了肾脏的初始形态学变化，这是巴尔干地方性肾病的特征。
