Mathur Priyanka, Mori Meera, Patel Foram, Upadhyay Khushali, Baxi Darshee, Desai Arpita
Department of Chemistry, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara, Gujarat 390002, India.
Department of Biomedical and Life Sciences, School of Science, Navrachana University, Vadodara, Gujarat 391410, India.
ACS Omega. 2025 May 20;10(21):21939-21950. doi: 10.1021/acsomega.5c01980. eCollection 2025 Jun 3.
The supramolecular architectures were designed from lemon-derived carbon dots (LCDs) and curcuminoids. Curcuminoids were used to link the carbon dots to create a supramolecular architecture via an ester linkage. The optical characteristics of curcuminoid-linked lemon carbon dots (CL-LCDs) demonstrated that CL-LCDs-1 can be used for bioimaging applications among all of the LCD derivatives. The HR-TEM and FEG-SEM images showed that the size of all CL-LCD derivatives is nearly 10 nm, which is ideal for the development of effective drug delivery systems. The CL-LCDs were used to encapsulate the anticancer drug methotrexate, which demonstrated a sustained drug release profile under pH stimulus. CL-LCDs-3 exhibited a 27.50% cumulative release at pH 5.5 after 7 days. At pH 7.4, CL-LCDs-3 showed a 19.73% cumulative drug release. MTX-loaded CL-LCDs-1 showed the best anticancer activity against HeLa cells, and the photoluminescence was recovered after the drug release, showing its promising application in the field of tumor imaging.
超分子结构由柠檬衍生的碳点（LCDs）和姜黄素类化合物设计而成。姜黄素类化合物用于连接碳点，通过酯键形成超分子结构。姜黄素类化合物连接的柠檬碳点（CL-LCDs）的光学特性表明，在所有LCD衍生物中，CL-LCDs-1可用于生物成像应用。高分辨率透射电子显微镜（HR-TEM）和场发射扫描电子显微镜（FEG-SEM）图像显示，所有CL-LCD衍生物的尺寸接近10nm，这对于开发有效的药物递送系统是理想的。CL-LCDs用于包封抗癌药物甲氨蝶呤，在pH刺激下表现出持续的药物释放曲线。7天后，CL-LCDs-3在pH 5.5时的累积释放率为27.50%。在pH 7.4时，CL-LCDs-3的药物累积释放率为19.73%。负载甲氨蝶呤的CL-LCDs-1对HeLa细胞表现出最佳的抗癌活性，药物释放后光致发光恢复，显示出其在肿瘤成像领域的应用前景。
