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碳点作为癌症诊断与治疗的有前景工具。

Carbon Dots as Promising Tools for Cancer Diagnosis and Therapy.

作者信息

Nocito Giuseppe, Calabrese Giovanna, Forte Stefano, Petralia Salvatore, Puglisi Caterina, Campolo Michela, Esposito Emanuela, Conoci Sabrina

机构信息

Department of Chemistry, Biology, Pharmacy and Environmental Science, University of Messina, 98122 Messina, Italy.

IOM Ricerca, Viagrande, 95029 Catania, Italy.

出版信息

Cancers (Basel). 2021 Apr 21;13(9):1991. doi: 10.3390/cancers13091991.

Abstract

Carbon Dots (CDs) are the latest members of carbon-based nanomaterials, which since their discovery have attracted notable attention due to their chemical and mechanical properties, brilliant fluorescence, high photostability, and good biocompatibility. Together with the ease and affordable preparation costs, these intrinsic features make CDs the most promising nanomaterials for multiple applications in the biological field, such as bioimaging, biotherapy, and gene/drug delivery. This review will illustrate the most recent applications of CDs in the biomedical field, focusing on their biocompatibility, fluorescence, low cytotoxicity, cellular uptake, and theranostic properties to highlight above all their usefulness as a promising tool for cancer diagnosis and therapy.

摘要

碳点(CDs)是碳基纳米材料的最新成员,自发现以来,因其化学和机械性能、出色的荧光、高光稳定性和良好的生物相容性而备受关注。再加上制备简便且成本低廉,这些内在特性使碳点成为生物领域多种应用中最具前景的纳米材料,如生物成像、生物治疗以及基因/药物递送。本综述将阐述碳点在生物医学领域的最新应用,重点关注其生物相容性、荧光、低细胞毒性、细胞摄取和诊疗特性,以突出其作为癌症诊断和治疗的有前景工具的实用性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e681/8122497/8bc36722946a/cancers-13-01991-g001.jpg

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