Litot Clara, Vansteelandt Marieke, Ortiz Sergio, Barakat Fatima, Crossay Elise, Titton Doriane, Bourgeade-Delmas Sandra, Amasifuen Carlos, Graton Jérôme, Jacquemin Denis, Stigliani Jean-Luc, Haddad Mohamed, Fabre Nicolas
UMR 152 Pharma Dev, Université de Toulouse, IRD, UPS, Toulouse 31062, France.
UMR 7200 Therapeutic Innovation Laboratory, CNRS, Strasbourg Institute for drug Discovery and Development (IMS), Strasbourg University, Illkirch-Graffenstaden, Strasbourg 67000, France.
ACS Omega. 2025 May 19;10(21):21738-21746. doi: 10.1021/acsomega.5c01292. eCollection 2025 Jun 3.
From an endophytic strain of Cophinforma mamane isolated from the leaves of Bixa orellana, a previously undescribed γ-butyrolactone compound () and three new cyclopentapeptides (-) have been isolated from the same strain, along with the known (4-striatisporolide A (). Their structures were elucidated through extensive spectral analysis and DP4+ calculations. The two γ-butyrolactone derivatives (, ) exhibited moderate inhibitory activity against axenic Leishmania infantum amastigotes (IC = 13.33 and 4.43 μM, respectively), while only compound displayed cytotoxic activity on Jurkat cells (17% growth inhibition at 1 μg/mL) and weak antibacterial activity against Enterococcus faecalis (MIC = 64 μg/mL).
从一种从红木（Bixa orellana）叶片中分离得到的内生菌株科菲菌属（Cophinforma mamane）中，已从同一菌株中分离出一种先前未描述的γ-丁内酯化合物（）和三种新的环五肽（-），以及已知的（4-条纹孢菌素A（）。通过广泛的光谱分析和DP4+计算阐明了它们的结构。这两种γ-丁内酯衍生物（，）对无菌的婴儿利什曼原虫无鞭毛体表现出中等抑制活性（IC分别为13.33和4.43 μM），而只有化合物对Jurkat细胞表现出细胞毒性活性（在1 μg/mL时生长抑制17%），并且对粪肠球菌表现出弱抗菌活性（MIC = 64 μg/mL）。
