Hai Ping, Li Qiang, Ma Xiao Fei, Jia Hai Yan, He Yun Qing, Yang Jin, Li Xian Yan, Luo Zhi Qiang, Yang Mei Ling, Gao Yuan, Wang Hong Peng, Yang Jian
Key Lab of Process Analysis and Control of Sichuan Universities, Faculty of Materials and Chemical Engineering, Yibin University, Yibin 644000, China.
Key Laboratory of Stress Physiology and Ecology in Cold and Arid Regions of Gansu Province, Department of Ecology and Agriculture Research, Northwest Institute of Eco-Environment and Resources, Chinese Academy of Sciences, Lanzhou 730000, China.
ACS Omega. 2025 May 21;10(21):21846-21856. doi: 10.1021/acsomega.5c01825. eCollection 2025 Jun 3.
Agriophyllum squarrosum (sand rice), a resilient desert plant with ecological and nutritional significance, has applications in food, forage, and traditional medicine. Despite its traditional use in China for treating inflammatory symptoms such as ophthalmia, urethritis, and oral ulcers, limited phytochemical studies restrict its pharmacological exploration. In this study, ten undescribed isoflavanone derivatives, including dihydroisoflavanones (-) and coumaronochromones (-), along with thirty-six known compounds (-), were isolated from A. squarrosum. The new structures were determined by NMR, HRESIMS, and DFT calculations of their NMR and ECD data, which also led to the structural revision of suaeglaucin C. Anti-inflammatory assays revealed compounds and as potent inhibitors, outperforming L-NMMA, and the structure-activity relationship of the optically active dihydroisoflavones was briefly discussed. All compounds were isolated from this plant for the first time, except for compounds , , and .
沙米（Agriophyllum squarrosum）是一种具有生态和营养意义的适应性强的沙漠植物，在食品、饲料和传统医学中都有应用。尽管在中国它传统上用于治疗诸如眼炎、尿道炎和口腔溃疡等炎症症状，但有限的植物化学研究限制了其药理学探索。在本研究中，从沙米中分离出了十种未描述的异黄酮衍生物，包括二氢异黄酮（-）和香豆素色酮（-），以及三十六种已知化合物（-）。通过核磁共振（NMR）、高分辨电喷雾电离质谱（HRESIMS）以及对其核磁共振和电子圆二色光谱（ECD）数据的密度泛函理论（DFT）计算确定了新结构，这也导致了对异光黄素C结构的修正。抗炎试验表明化合物 和 是有效的抑制剂，优于L-硝基精氨酸甲酯（L-NMMA），并简要讨论了光学活性二氢异黄酮的构效关系。除化合物 、 和 外，所有化合物均首次从该植物中分离得到。
