Yao Hui-Na, Zhang Hang, Wang Wen-Xuan, Zan Ni-Li, Liu Di-Fa, Zhao Yun-Fang, Zheng Jiao, Tu Peng-Fei, Li Jun
Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine Beijing 100029, China.
State Key Laboratory of Innovative Natural Medicine and Traditional Chinese Medicine Injections, Jiangxi Qingfeng Pharmaceutical Co., Ltd. Ganzhou 341000, China.
Zhongguo Zhong Yao Za Zhi. 2020 May;45(10):2411-2416. doi: 10.19540/j.cnki.cjcmm.20200220.202.
Two new phenylpropanoid amide glycosides and ten analogues were isolated from the CH_2Cl_2 layer of 95% ethanol extract of the whole plants of Corydalis racemosa by using various chromatographic techniques, including silica gel, Sephadex LH-20, ODS column chromatographies, and semi-preparative HPLC. Their structures were identified on the basis of physicochemical properties, MS, NMR, and IR spectroscopic data as N-cis-sinapoyltyramine-4'-O-β-glucoside(1), N-cis-sinapoyl-3-methoxytyramine-4'-O-β-glucoside(2), N-cis-sinapoyltyramine(3), N-cis-feruloyltyramine(4), N-trans-cinnamoyltyramine(5), N-trans-feruloylphenethylamine(6), N-trans-p-methoxycinnamoyl-3-hydoxyoctopamine(7), N-cis-feruloyl-3-methoxytyramine(8), N-trans-feruloyltyramine(9), N-trans-feruloyl-3-methoxytyramine(10), N-trans-sinapoyltyramine(11), and N-trans-p-coumaroyltyramine(12). Compounds 1 and 2 are new compounds. Compounds 3-7 are obtained from the plants of Papaveraceae for the first time, and compounds 8-12 are firstly isolated from C. racemosa.
采用硅胶柱色谱、葡聚糖凝胶LH - 20柱色谱、ODS柱色谱及半制备高效液相色谱等多种色谱技术，从延胡索全草95%乙醇提取物的二氯甲烷层中分离得到2个新的苯丙素酰胺苷类化合物及10个类似物。根据其理化性质、质谱、核磁共振和红外光谱数据，鉴定它们的结构分别为N - 顺式芥子酰酪胺 - 4'-O-β - 葡萄糖苷（1）、N - 顺式芥子酰 - 3 - 甲氧基酪胺 - 4'-O-β - 葡萄糖苷（2）、N - 顺式芥子酰酪胺（3）、N - 顺式阿魏酰酪胺（4）、N - 反式肉桂酰酪胺（5）、N - 反式阿魏酰苯乙胺（6）、N - 反式 - 对甲氧基肉桂酰 - 3 - 羟基章鱼胺（7）、N - 顺式阿魏酰 - 3 - 甲氧基酪胺（8）、N - 反式阿魏酰酪胺（9）、N - 反式阿魏酰 - 3 - 甲氧基酪胺（10）、N - 反式芥子酰酪胺（11）和N - 反式对香豆酰酪胺（12）。化合物1和2为新化合物。化合物3 - 7首次从罂粟科植物中获得，化合物8 - 12首次从延胡索中分离得到。
