Fazlıoğlu Nevin, Aydın Cihan, Demirkıran Aykut, Özkaramanlı Gür Demet, Yılmaz Ahsen, Çelikkol Aliye
Department of Pulmonary Medicine, Faculty of Medicine, Tekirdag Namik Kemal University, Tekirdag, Turkey.
Department of Cardiology, Faculty of Medicine, Tekirdag Namik Kemal University, Tekirdag, Turkey.
Nat Sci Sleep. 2025 Jun 3;17:1175-1190. doi: 10.2147/NSS.S509757. eCollection 2025.
Obstructive sleep apnea syndrome (OSAS) increases the risk of vascular dysfunction by causing hypoxemia due to recurrent obstructions in the upper airway. This can put pressure on the vasculature and impair endothelial function. SCUBE-1 gains importance in OSAS as a biomarker that may reflect this dysfunction. We focused in this study on the association between levels of SCUBE-1 and endothelial dysfunction in patients suffering from OSAS.
A study population of 75 individuals participated in the study. Participants were categorized as normal (n=18), mild OSAS (n=22), moderate OSAS (n=19) and severe OSAS (n=16) according to polysomnography findings. Evaluation parameters included SCUBE-1 levels, polysomnography measurements, flow-mediated dilatation (FMD), carotid intima-media thickness (CIMT), and comprehensive laboratory analyses.
SCUBE-1 levels were significantly higher in the severe OSAS group (15.8 ± 4.2 ng/mL, p<0.001). SCUBE-1 showed a moderate negative correlation with FMD (r = -0.248, p < 0.001) and a significant negative correlation with CIMT (r = -0.512, p < 0.001). ROC analysis demonstrated good diagnostic accuracy (AUC: 0.871, 95% CI: 0.797-0.945) for SCUBE-1 in identifying severe OSAS.
OSAS severity correlates with the rise in SCUBE-1 levels, and this biomarker may serve as an important attribute in profiling endothelial dysfunction. SCUBE-1 can indeed be an effective biomarker to identify subtle changes in the vascular biology of OSAS patients and aid early interventions.
阻塞性睡眠呼吸暂停综合征（OSAS）由于上气道反复阻塞导致低氧血症，从而增加血管功能障碍的风险。这会对脉管系统造成压力并损害内皮功能。信号肽CUB域含蛋白1（SCUBE-1）作为一种可能反映这种功能障碍的生物标志物，在OSAS中具有重要意义。本研究聚焦于OSAS患者中SCUBE-1水平与内皮功能障碍之间的关联。
75名个体参与了本研究。根据多导睡眠图检查结果，参与者被分为正常组（n = 18）、轻度OSAS组（n = 22）、中度OSAS组（n = 19）和重度OSAS组（n = 16）。评估参数包括SCUBE-1水平、多导睡眠图测量、血流介导的血管舒张（FMD）、颈动脉内膜中层厚度（CIMT）以及全面的实验室分析。
重度OSAS组的SCUBE-1水平显著更高（15.8±4.2 ng/mL，p<0.001）。SCUBE-1与FMD呈中度负相关（r = -0.248，p < 0.001），与CIMT呈显著负相关（r = -0.512，p < 0.001）。ROC分析表明，SCUBE-1在识别重度OSAS方面具有良好的诊断准确性（AUC：0.871，95%CI：0.797 - 0.945）。
OSAS的严重程度与SCUBE-1水平的升高相关，并且这种生物标志物可能是描述内皮功能障碍的一个重要指标。SCUBE-1确实可以成为一种有效的生物标志物，用于识别OSAS患者血管生物学的细微变化并有助于早期干预。
