Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Korea University, Seoul, Republic of Korea.
Department of Biostatistics, College of Medicine, Korea University, Seoul, Republic of Korea.
Diabetes Res Clin Pract. 2018 Feb;136:100-107. doi: 10.1016/j.diabres.2017.11.031. Epub 2017 Dec 1.
Meteorin-like (Metrnl) was recently identified as a novel adipomyokine induced by exercise and cold exposure. Metrnl improves glucose tolerance, increases systemic energy expenditure, induces white adipose browning, and promotes anti-inflammatory gene programs in obese/diabetic mice. However, the relationship of Metrnl with diabetes and cardiometabolic risk variables in humans has not been explored.
In 800 subjects (400 patients with type 2 diabetes and 400 non-diabetes), Metrnl concentration was measured with an enzyme-linked immunosorbent assay, and the correlations of Metrnl level with anthropometric parameters, lifestyle factors, body composition values, and laboratory measurements were assessed.
Metrnl concentration was significantly higher in patients with diabetes than in those without diabetes [median (inter-quartile range); diabetes: 1219.9 (1020.6, 1535.6), non-diabetes: 1131.2 (993.1, 1313.6) pg/ml, P < .001]. After adjustment for age and sex, Metrnl level was significantly associated with fasting plasma glucose, blood pressure, lipid profile, and eGFR, but not with BMI or percent body fat. Multiple stepwise regression analysis exhibited that Metrnl level was independently associated with diabetes status (P < .001), eGFR (P < .001), and total cholesterol (P = .026) (R = 0.127). In multiple logistic regression analysis, the odds ratio for the risk of diabetes was 3.53 (95% confidence interval: 2.04-6.10) in the highest tertile of Metrnl compared to the lowest after adjustment for confounding factors.
This study is the first to demonstrate that Metrnl level is elevated in human subjects with type 2 diabetes and is inversely related to various cardiometabolic risk factors, including renal function.
最近发现 Meteorin-like（Metrnl）是一种新型的脂肪-肌因子，可由运动和冷暴露诱导产生。Metrnl 可改善葡萄糖耐量，增加全身能量消耗，诱导白色脂肪棕色化，并促进肥胖/糖尿病小鼠的抗炎基因程序。然而，Metrnl 与人类糖尿病和心血管代谢风险因素的关系尚未得到探索。
在 800 名受试者（400 名 2 型糖尿病患者和 400 名非糖尿病患者）中，使用酶联免疫吸附测定法测量 Metrnl 浓度，并评估 Metrnl 水平与人体测量参数、生活方式因素、身体成分值和实验室测量值的相关性。
糖尿病患者的 Metrnl 浓度明显高于非糖尿病患者[中位数（四分位数范围）；糖尿病：1219.9（1020.6，1535.6），非糖尿病：1131.2（993.1，1313.6）pg/ml，P<.001]。在校正年龄和性别后，Metrnl 水平与空腹血糖、血压、血脂谱和 eGFR 显著相关，但与 BMI 或体脂百分比无关。逐步多元回归分析显示，Metrnl 水平与糖尿病状态独立相关（P<.001）、eGFR（P<.001）和总胆固醇（P=.026）（R²=0.127）。在多元逻辑回归分析中，与最低三分位组相比，Metrnl 最高三分位组患糖尿病的风险比为 3.53（95%置信区间：2.04-6.10），校正混杂因素后。
这项研究首次表明，Metrnl 水平在 2 型糖尿病患者中升高，与各种心血管代谢危险因素（包括肾功能）呈负相关。
