Drivsholm A, Lisse I, Philip P
Scand J Haematol. 1985 Jul;35(1):35-7. doi: 10.1111/j.1600-0609.1985.tb00796.x.
On the basis of the literature, so-called secondary acute nonlymphocytic leukaemia (S-ANLL) in myelomatosis is reviewed. Using the banding technique, cytogenetic changes including hypodiploidy and partially or totally missing chromosomes # 5 and # 7 are recorded. The findings are in accordance with the cytogenetic changes seen in S-ANLL in other malignancies which have been treated with cytostatics, especially alkylating agents. So, S-ANLL in myelomatosis seems to be a result of treatment with cytostatics, though a causal relationship has to be documented.
基于文献，对骨髓瘤病中所谓的继发性急性非淋巴细胞白血病（S-ANLL）进行了综述。运用显带技术，记录了包括亚二倍体以及5号和7号染色体部分或完全缺失在内的细胞遗传学变化。这些发现与其他接受过细胞抑制剂尤其是烷化剂治疗的恶性肿瘤中S-ANLL所观察到的细胞遗传学变化一致。所以，骨髓瘤病中的S-ANLL似乎是细胞抑制剂治疗的结果，尽管因果关系还有待证实。
