孕激素是引发黄鳝（Monopterus albus）性逆转的一个潜在诱因。
Progestogen is a potential trigger initiating sex inversion in rice field eel (Monopterus albus).
作者信息
Qu Xiancheng, Jiang Jiaoyun, Li Min, Ye Jianhua, Pan Lisa, Zhang Qinhua, Zhong Guofang, Zhu Xinchao, Du Yifang, Li Xianhui
机构信息
National Demonstration Center for Experimental Fisheries Science Education, Shanghai Ocean University, Shanghai, 201306, China.
Key Laboratory of Ecology of Rare and Endangered Species and Environmental Protection, Ministry of Education, Guangxi Normal University, Guilin, 541004, China.
出版信息
Fish Physiol Biochem. 2025 Jun 9;51(3):109. doi: 10.1007/s10695-025-01524-9.
The rice field eel or swamp eel (Monopterus albus) is a hermaphroditic freshwater teleost fish that transitions from a functional female to a functional male. However, the biological mechanism of sex inversion in this species remains unclear. Here we clone the 5' proximal flanking region of the rice field eel dmrt1 gene and find that the progesterone response element (PRE) and androgen response element (ARE) uniquely exist in this region. More importantly, based on reporter gene analysis, in vitro tissue culture, and progestogen hormone level assays, we reveal that progestogen is the prerequisite for the sex inversion of the rice field eel, and androgen plays an important role in the positive regulation of the sex inversion process. Collectively, our results suggest that progestogen is the trigger that initiates the rice field eel's sex trans-differentiation during final oocyte maturation and clarifies the biological mechanism of sex inversion in the rice field eel.
黄鳝（Monopterus albus）是一种雌雄同体的淡水硬骨鱼，会从功能性雌性转变为功能性雄性。然而，该物种性别反转的生物学机制仍不清楚。在此，我们克隆了黄鳝dmrt1基因的5'近端侧翼区域，发现孕酮反应元件（PRE）和雄激素反应元件（ARE）仅存在于该区域。更重要的是，基于报告基因分析、体外组织培养和孕激素激素水平测定，我们揭示了孕激素是黄鳝性别反转的先决条件，雄激素在性别反转过程的正向调节中起重要作用。总体而言，我们的结果表明，孕激素是在最终卵母细胞成熟过程中启动黄鳝性别转分化的触发因素，并阐明了黄鳝性别反转的生物学机制。
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