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[利多卡因持续输注用于妇产科手术术后镇痛]

[Postoperative analgesia by constant flow injection of lignocaine in obstetrical and gynecologic surgery].

作者信息

Jullien Y, de Rodez M, Desch G, Descomps B, du Cailar J

出版信息

Ann Anesthesiol Fr. 1979;20(4):303-12.

PMID:40489
Abstract

154 surgical patients were given post-operative analgesia by peridural injection at a constant flow in the post-operative period after obstetric or gynecological surgery. These patients received 536.2 +/- 105.3 mu mol.h-1 (145.2 +/- 28.5 mg.h-1) of lignocaine for 46.97 +/- 15.56 h through a catheter omserted between L1-L2. The drug was given in concentrations which varied between: 27.7 to 18.5 m mol.l-1 (0.75 to 0.50 p. 100) depending on the age; and the volume varied between 17.5 to 30 ml.h-1 depending on the height. Satisfactory analgesia in 87 p. 100 of cases allowed all supplementary analgesia to be stopped. The only significant hemodynamic effect was a slight tachycardia (+ 15 p. 100). Two undesirable side effects were noted: a transitory but well-defined (type 2 or 3) motor paralysis, and an accumulation of plasma lignocaine (40 mu mol.l-1 (1.1 microgram.ml-1) at 48 h).

摘要

154例外科手术患者在产科或妇科手术后的术后期间通过硬膜外持续输注给予术后镇痛。这些患者通过L1 - L2之间插入的导管接受了46.97±15.56小时的536.2±105.3μmol·h⁻¹(145.2±28.5mg·h⁻¹)的利多卡因。药物浓度根据年龄在27.7至18.5mmol·L⁻¹(0.75至0.50%)之间变化;输注速度根据身高在17.5至30ml·h⁻¹之间变化。87%的病例镇痛效果满意,所有辅助镇痛措施均停止使用。唯一显著的血流动力学效应是轻微的心动过速(增加15%)。记录到两个不良副作用:短暂但明确的(2型或3型)运动麻痹,以及血浆利多卡因蓄积(48小时时为40μmol·L⁻¹(1.1μg·ml⁻¹))。

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