Charles Joseph W, Moriarty Samantha K, Fournier Danielle I, Winterbauer Neil E, Cooper Emily A, Todd Travis P
Department of Psychological Science, University of Vermont, Burlington, Vermont 05405, USA.
Herbert Wertheim School of Optometry and Vision Science, University of California, Berkeley, Berkeley, California 94720, USA.
Learn Mem. 2025 Jun 9;32(5-6). doi: 10.1101/lm.054103.125. Print 2025 May-Jun.
Extinguished responses are prone to renew outside the context where extinction occurred. Two experiments compared extinction and renewal following either a 1 day conditioning-to-extinction interval or a 27 day interval. Rats received tone-shock pairings in Context A, and extinction in Context B. Testing occurred in Context A (Experiment 1) or C (Experiment 2). Extinction occurred at a similar rate after both retention intervals. Robust renewal was also observed and was not affected by the conditioning-to-extinction retention interval. Results are discussed with respect to prior research on the timing of extinction, the neurobiology of recent and remote memory retrieval, and translational relevance.
消退反应易于在发生消退的情境之外重新出现。两项实验比较了在1天的条件作用至消退间隔或27天间隔后的消退和重新出现情况。大鼠在情境A中接受音调-电击配对，在情境B中进行消退。测试在情境A（实验1）或C（实验2）中进行。在两个保留间隔后，消退以相似的速率发生。还观察到了强烈的重新出现，且其不受条件作用至消退保留间隔的影响。结合先前关于消退时间、近期和远期记忆检索的神经生物学以及转化相关性的研究对结果进行了讨论。
