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Tirzepatide differentially affects body weight in mice and humans.

作者信息

Novikoff Aaron, Müller Timo D

机构信息

Institute for Diabetes and Obesity, Helmholtz Munich, Neuherberg, Germany.

German Center for Diabetes Research (DZD), Neuherberg, Germany.

出版信息

Nat Rev Endocrinol. 2025 Aug;21(8):462-463. doi: 10.1038/s41574-025-01139-3.

DOI:10.1038/s41574-025-01139-3
PMID:40490496
Abstract
摘要

相似文献

1
Tirzepatide differentially affects body weight in mice and humans.替尔泊肽对小鼠和人类的体重有不同影响。
Nat Rev Endocrinol. 2025 Aug;21(8):462-463. doi: 10.1038/s41574-025-01139-3.
2
Efficacy and safety of once-weekly tirzepatide in Japanese participants with type 2 diabetes who have obesity or overweight: Subpopulation analysis of the SURMOUNT-2 trial.在患有肥胖或超重的日本2型糖尿病参与者中,每周一次注射替尔泊肽的疗效和安全性:SURMOUNT-2试验的亚组分析
Diabetes Obes Metab. 2025 Aug;27(8):4557-4566. doi: 10.1111/dom.16500. Epub 2025 Jun 9.
3
Management of type 2 diabetes with the dual GIP/GLP-1 receptor agonist tirzepatide: a systematic review and meta-analysis.使用双重 GIP/GLP-1 受体激动剂替西帕肽治疗 2 型糖尿病:系统评价和荟萃分析。
Diabetologia. 2022 Aug;65(8):1251-1261. doi: 10.1007/s00125-022-05715-4. Epub 2022 May 17.
4
Tirzepatide for Obesity Treatment and Diabetes Prevention.替尔泊肽用于肥胖治疗和糖尿病预防。
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Dose-Dependent Efficacy and Safety of Tirzepatide for Weight Loss in Non-diabetic Adults With Obesity: A Systematic Review and Meta-analysis of Randomized Controlled Trials.替尔泊肽用于非糖尿病肥胖成人减肥的剂量依赖性疗效和安全性:一项随机对照试验的系统评价和荟萃分析
Cureus. 2025 Jun 7;17(6):e85531. doi: 10.7759/cureus.85531. eCollection 2025 Jun.
6
Association of tirzepatide with cardiometabolic benefits in Chinese adults: post hoc subgroup analysis of SURMOUNT-CN study.替尔泊肽对中国成年人心脏代谢的益处:SURMOUNT-CN研究的事后亚组分析
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Tirzepatide as Compared with Semaglutide for the Treatment of Obesity.替尔泊肽与司美格鲁肽治疗肥胖症的比较
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Indirect comparative efficacy and safety of tirzepatide 10 and 15 mg versus semaglutide 2.4 mg for the management of obesity and overweight in patients with type 2 diabetes.替尔泊肽10毫克和15毫克与司美格鲁肽2.4毫克治疗2型糖尿病患者肥胖和超重的间接比较疗效与安全性
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The quantity, quality and findings of network meta-analyses evaluating the effectiveness of GLP-1 RAs for weight loss: a scoping review.评估胰高血糖素样肽-1受体激动剂(GLP-1 RAs)减肥效果的网状Meta分析的数量、质量及结果:一项范围综述
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The role of gut microbiota in Tirzepatide-mediated alleviation of high-fat diet-induced obesity.肠道微生物群在替尔泊肽介导的减轻高脂饮食诱导的肥胖中的作用。
Eur J Pharmacol. 2025 Sep 5;1002:177827. doi: 10.1016/j.ejphar.2025.177827. Epub 2025 Jun 12.

本文引用的文献

1
Tirzepatide did not impact metabolic adaptation in people with obesity, but increased fat oxidation.替尔泊肽对肥胖人群的代谢适应性没有影响,但增加了脂肪氧化。
Cell Metab. 2025 May 6;37(5):1060-1074.e4. doi: 10.1016/j.cmet.2025.03.011. Epub 2025 Apr 8.
2
Glucose-dependent insulinotropic polypeptide (GIP).葡萄糖依赖性促胰岛素多肽(GIP)。
Mol Metab. 2025 May;95:102118. doi: 10.1016/j.molmet.2025.102118. Epub 2025 Feb 28.
3
Specific loss of GIPR signaling in GABAergic neurons enhances GLP-1R agonist-induced body weight loss.
γ-氨基丁酸能神经元中胃抑制多肽受体(GIPR)信号的特异性缺失增强了胰高血糖素样肽-1受体(GLP-1R)激动剂诱导的体重减轻。
Mol Metab. 2025 May;95:102074. doi: 10.1016/j.molmet.2024.102074. Epub 2024 Nov 26.
4
Lead-in calorie restriction enhances the weight-lowering efficacy of incretin hormone-based pharmacotherapies in mice.限食可增强基于肠促胰岛素的药物疗法在小鼠模型中的减重效果。
Mol Metab. 2024 Nov;89:102027. doi: 10.1016/j.molmet.2024.102027. Epub 2024 Sep 13.
5
GIPR agonism mediates weight-independent insulin sensitization by tirzepatide in obese mice.GIPR 激动剂介导替西帕肽在肥胖小鼠中发挥不依赖体重的胰岛素增敏作用。
J Clin Invest. 2021 Jun 15;131(12). doi: 10.1172/JCI146353.
6
The glucose-dependent insulinotropic polypeptide (GIP) regulates body weight and food intake via CNS-GIPR signaling.葡萄糖依赖性胰岛素释放多肽(GIP)通过中枢神经系统-GIPR 信号来调节体重和食物摄入。
Cell Metab. 2021 Apr 6;33(4):833-844.e5. doi: 10.1016/j.cmet.2021.01.015. Epub 2021 Feb 10.
7
Semaglutide lowers body weight in rodents via distributed neural pathways.司美格鲁肽通过分布式神经通路降低啮齿动物的体重。
JCI Insight. 2020 Mar 26;5(6):133429. doi: 10.1172/jci.insight.133429.
8
Persistent metabolic adaptation 6 years after "The Biggest Loser" competition.“超级减肥王”比赛6年后的持续代谢适应
Obesity (Silver Spring). 2016 Aug;24(8):1612-9. doi: 10.1002/oby.21538. Epub 2016 May 2.
9
Changes in energy expenditure resulting from altered body weight.体重改变导致的能量消耗变化。
N Engl J Med. 1995 Mar 9;332(10):621-8. doi: 10.1056/NEJM199503093321001.